{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:33:19Z","timestamp":1781854399635,"version":"3.54.5"},"reference-count":20,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p> To test the hypothesis that the decrease in plasma pH contributes to the hyperventilation observed in humans in response to exercise at high workloads, five healthy male subjects performed a ramp exercise [maximal workload: 352 W (SD 35)] in a control situation and when arterialized plasma pH was maintained at the resting level (pH clamp) by intravenous infusion of sodium bicarbonate [129 mmol (SD 23), beginning at 59% maximal workload (SD 5)]. Bicarbonate infusion did not modify O<jats:sub>2<\/jats:sub> consumption (V\u0307o<jats:sub>2<\/jats:sub>) but significantly ( P &lt; 0.05) increased arterial Pco<jats:sub>2<\/jats:sub>, plasma bicarbonate concentration, and respiratory exchange ratio ( P &lt; 0.05). At the three highest workloads, pulmonary ventilation (V\u0307e) and V\u0307e\/V\u0307o<jats:sub>2<\/jats:sub> were \u223c5\u201310% lower ( P &lt; 0.05) when bicarbonate was infused than in the control situation, and hyperventilation was reduced by 15\u201330%. These data suggest that the decrease in plasma pH is one of the factors that contribute to the hyperventilation observed at high workloads. <\/jats:p>","DOI":"10.1152\/japplphysiol.00559.2006","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T20:45:52Z","timestamp":1157661952000},"page":"426-428","source":"Crossref","is-referenced-by-count":27,"title":["Bicarbonate infusion and pH clamp moderately reduce hyperventilation during ramp exercise in humans"],"prefix":"10.1152","volume":"102","author":[{"given":"Fran\u00e7ois","family":"P\u00e9ronnet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Aguilaniu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl-\u00c9tienne","family":"Juneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Faude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Kindermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018845"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868138"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00376434"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1249\/00003677-200607000-00002"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1139\/h94-028"},{"key":"R6","unstructured":"Forster HV. 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