{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:57:54Z","timestamp":1792706274569,"version":"4.5.0"},"reference-count":49,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:p>The immediate responses of the upper respiratory tract (URT) to the irritants acrolein and acetic acid were examined in healthy and allergic airway-diseased C57Bl\/6J mice. Acrolein (1.1 ppm) and acetic acid (330 ppm) vapors induced an immediate increase in flow resistance, as measured in the surgically isolated URT of urethane-anesthetized healthy animals. Acrolein, but not acetic acid, induced a small URT vasodilatory response. In awake spontaneously breathing mice, both vapors induced a prolonged pause at the start of expiration (a response mediated via stimulation of nasal trigeminal nerves) and an increase in total respiratory specific airway flow resistance, the magnitude of which was similar to that observed in the isolated URT. Both responses were significantly reduced in animals pretreated with large doses of capsaicin to defunctionalize sensory nerves, strongly suggesting a role for sensory nerves in development of these responses. The breathing pattern and\/or obstructive responses were enhanced in mice with ovalbumin-induced allergic airway disease. These results suggest that the primary responses to acrolein and acetic acid vapors are altered breathing patterns and airway obstruction, that sensory nerves play an important role in these responses, and that these responses are enhanced in animals with allergic airway disease.<\/jats:p>","DOI":"10.1152\/japplphysiol.00572.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:44:35Z","timestamp":1425415475000},"page":"1563-1571","source":"Crossref","is-referenced-by-count":50,"title":["Immediate sensory nerve-mediated respiratory responses to irritants in healthy and allergic airway-diseased mice"],"prefix":"10.1152","volume":"94","author":[{"given":"John B.","family":"Morris","sequence":"first","affiliation":[{"name":"University of Connecticut Pulmonary Research Consortium, Department of Pharmaceutical Sciences, University of Connecticut, Storrs 06269; and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Symanowicz","sequence":"additional","affiliation":[{"name":"University of Connecticut Pulmonary Research Consortium, Department of Pharmaceutical Sciences, University of Connecticut, Storrs 06269; and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua E.","family":"Olsen","sequence":"additional","affiliation":[{"name":"University of Connecticut Pulmonary Research Consortium, Department of Pharmaceutical Sciences, University of Connecticut, Storrs 06269; and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"Thrall","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Cloutier","sequence":"additional","affiliation":[{"name":"Pediatrics, University of Connecticut Health Center, Farmington, Connecticut 06032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea K.","family":"Hubbard","sequence":"additional","affiliation":[{"name":"University of Connecticut Pulmonary Research Consortium, Department of Pharmaceutical Sciences, University of Connecticut, Storrs 06269; and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0110001"},{"key":"B1a","doi-asserted-by":"publisher","DOI":"10.3109\/10408447309082020"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0015-6264(81)90513-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(85)90376-X"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00210-3"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.5.1187"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.6.1391"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.2.695"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3109\/10408449209089882"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1159\/000024056"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1959.14.4.541"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.487"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5464.306"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90165-8"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0027715"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119039"},{"key":"B18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0031-6997(25)06664-5","volume":"43","author":"Holzer P.","year":"1991","journal-title":"Pharmacol Rev"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.6.9908051"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.6.9808078"},{"key":"B21","first-page":"71","volume":"60","author":"Jacobson SB","year":"2001","journal-title":"Toxicol Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1139\/y95-125"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-05-01844.1999"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(97)00130-9"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/089583799196727"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1080\/08958370290084511"},{"key":"B27","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/toxsci\/54.1.222","volume":"54","author":"Morris JB","year":"2000","journal-title":"Toxicol Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.5.1877"},{"key":"B29","first-page":"173","volume":"48","author":"Morris JB","year":"1999","journal-title":"Toxicol Sci"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3109\/10408449109089879"},{"key":"B31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0022-3565(25)10299-1","volume":"264","author":"Petersson G","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3109\/01902149509031765"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1159\/000024054"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.22.2.3620"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.4.1386"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91597-T"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(98)01261-9"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/49.2.225"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1080\/089583701316941320"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-15-06497.1999"},{"key":"B41","first-page":"479","volume":"66","author":"Symanowicz PT","year":"2002","journal-title":"Toxicol Sci"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168777"},{"key":"B43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-6997(24)01403-0","volume":"51","author":"Szallasi A","year":"1999","journal-title":"Pharmacol Rev"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/rr62"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.110153"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.128.3.444"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00370-5"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.59.1.457"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2798"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65449-1"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00572.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T17:53:11Z","timestamp":1747763591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00572.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,1]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4,1]]}},"alternative-id":["10.1152\/japplphysiol.00572.2002"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00572.2002","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,1]]}}}