{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:08:32Z","timestamp":1789891712571,"version":"4.0.1"},"reference-count":37,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2013,3,15]]},"abstract":"<jats:p> High fructose consumption contributes to metabolic syndrome incidence, whereas exercise training promotes several beneficial adaptations. In this study, we demonstrated the preventive role of exercise training in the metabolic syndrome derangements in a rat model. Wistar rats receiving fructose overload in drinking water (100 g\/l) were concomitantly trained on a treadmill (FT) or kept sedentary (F) for 10 wk. Control rats treated with normal water were also submitted to exercise training (CT) or sedentarism (C). Metabolic evaluations consisted of the Lee index and glycemia and insulin tolerance test (kITT). Blood pressure (BP) was directly measured, whereas heart rate (HR) and BP variabilities were evaluated in time and frequency domains. Renal sympathetic nerve activity was also recorded. F rats presented significant alterations compared with all the other groups in insulin resistance (in mg\u00b7dl<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>: F: 3.4 \u00b1 0.2; C: 4.7 \u00b1 0.2; CT: 5.0 \u00b1 0.5 FT: 4.6 \u00b1 0.4), mean BP (in mmHG: F: 117 \u00b1 2; C: 100 \u00b1 2; CT: 98 \u00b1 2; FT: 105 \u00b1 2), and Lee index (in g\/mm: F = 0.31 \u00b1 0.001; C = 0.29 \u00b1 0.001; CT = 0.27 \u00b1 0.002; FT = 0.28 \u00b1 0.002), confirming the metabolic syndrome diagnosis. Exercise training blunted all these derangements. Additionally, FS group presented autonomic dysfunction in relation to the others, as seen by an \u223c50% decrease in baroreflex sensitivity and 24% in HR variability, and increases in sympathovagal balance (140%) and in renal sympathetic nerve activity (45%). These impairments were not observed in FT group, as well as in C and CT. Correlation analysis showed that both Lee index and kITT were associated with vagal impairment caused by fructose. Therefore, exercise training plays a preventive role in both autonomic and hemodynamic alterations related to the excessive fructose consumption. <\/jats:p>","DOI":"10.1152\/japplphysiol.00586.2012","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T09:28:41Z","timestamp":1358501321000},"page":"786-791","source":"Crossref","is-referenced-by-count":53,"title":["Preventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development"],"prefix":"10.1152","volume":"114","author":[{"given":"Ivana Cinthya","family":"Moraes-Silva","sequence":"first","affiliation":[{"name":"Hypertension Unit, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Mostarda","sequence":"additional","affiliation":[{"name":"Hypertension Unit, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson Dias","family":"Moreira","sequence":"additional","affiliation":[{"name":"Hypertension Unit, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleiton Augusto Santos","family":"Silva","sequence":"additional","affiliation":[{"name":"Nephrology Department, Federal University of Sao Paulo, Sao Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Hypertension Unit, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia","family":"de Angelis","sequence":"additional","affiliation":[{"name":"Nove de Julho University, Sao Paulo, Brazil; 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