{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:37:01Z","timestamp":1790257021288,"version":"4.1.0"},"reference-count":32,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p>The purpose was to investigate the contribution of mechanical damage to sarcomeres to the greater susceptibility of dystrophic muscle fibers to contraction-induced injury. Single stretches provide an effective method for studying mechanical factors that contribute to the initiation of contraction-induced injury. We hypothesized that, after single stretches, the deficits in isometric force would be greater for muscles of mdx than C57BL\/10 mice, whereas membrane damage would be minimal for all muscles. Extensor digitorum longus (EDL) and soleus muscles of mice were removed under anesthesia with Avertin (tribromoethanol). During the plateau of a maximum isometric contraction in vitro, muscles were stretched through single strains of 20-60% fiber length. Isometric force was remeasured 1 min later, and muscles were then incubated in procion orange dye to identify fibers with membrane damage. Force deficits at 1 min were two- to threefold greater for EDL muscles of mdx compared with C57BL\/10 mice, whereas no significant differences were observed between soleus muscles of mdx and C57BL\/10 mice. For all muscles, membrane damage was minimal and not significantly increased by single stretches for either strain of mice. These data support a critical role of dystrophin maintaining sarcomere stability in EDL muscles, whereas soleus muscles retain abilities, in the absence of dystrophin, not different from control muscles to resist sarcomere damage.<\/jats:p>","DOI":"10.1152\/japplphysiol.00587.2003","type":"journal-article","created":{"date-parts":[[2004,1,30]],"date-time":"2004-01-30T20:14:01Z","timestamp":1075493641000},"page":"633-638","source":"Crossref","is-referenced-by-count":77,"title":["Susceptibility to sarcomere injury induced by single stretches of maximally activated muscles of\n                    <i>mdx<\/i>\n                    mice"],"prefix":"10.1152","volume":"96","author":[{"given":"Christina M.","family":"Consolino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan V.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.649bj.x"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005364713451"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017279"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.2.661"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020980"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1007\/BF01739857"},{"key":"REF7","doi-asserted-by":"crossref","unstructured":"Clarke MSF\n                      , Khakee R, and McNeil PL.\n                      Loss of cytoplasmic basic fibroblast growth factor from physiologically wounded myofibers of normal and dystrophic muscle.\n                      J Cell Sci\n                      106\n                      : 121-133, 1993.","DOI":"10.1242\/jcs.106.1.121"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880151008"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051108"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150508"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(92)81845-3"},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp012894"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250407"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1988.tb08446.x"},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018324"},{"key":"REF16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.5.H1548"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00591.x"},{"key":"REF18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.4.C1290"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1997.sp022038"},{"key":"REF20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.5.C1438"},{"key":"REF21","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880171206"},{"key":"REF22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.1.119"},{"key":"REF23","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90058-8"},{"key":"REF24","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)00276-T"},{"key":"REF25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3710"},{"key":"REF26","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.2.371"},{"key":"REF27","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(93)81482-6"},{"key":"REF28","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019645"},{"key":"REF29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.3.1421"},{"key":"REF30","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90463-1"},{"key":"REF31","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.6.1259"},{"key":"REF32","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(91)90309-U"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00587.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T01:35:09Z","timestamp":1623634509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00587.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1152\/japplphysiol.00587.2003"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00587.2003","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}