{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:40:36Z","timestamp":1761986436099},"reference-count":43,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p> Patients with chronic bronchial asthma show a depressed ventilatory response to hypoxia (DVH), but the underlying mechanism remains unclear. We tested whether DVH existed in ovalbumin (Ova)-treated guinea pigs, an established animal model of asthma. Twelve guinea pigs were exposed to Ova (1% in saline) or saline aerosol (control) for 5 min, 5 days\/wk, for 2 wk. After completing aerosol exposure, the animals were anesthetized and exposed to systemic hypoxia. Ova treatment had no effects on animal body weight, baseline cardiorespiratory variables, or arterial blood O<jats:sub>2<\/jats:sub> and CO<jats:sub>2<\/jats:sub> tensions, but it attenuated the ventilatory response to hypoxia (10 breaths of pure N<jats:sub>2<\/jats:sub>) by 65% ( P &lt; 0.05). When the animals were subjected to intracarotid injections of sodium cyanide (20 \u03bcg) and doxapram (2 mg) to selectively stimulate carotid chemoreceptors, the ventilatory responses were reduced by 50% ( P &lt; 0.05) and 74% ( P &lt; 0.05), respectively. In contrast, Ova exposure failed to affect the ventilatory response to CO<jats:sub>2<\/jats:sub> (7% CO<jats:sub>2<\/jats:sub>-21% O<jats:sub>2<\/jats:sub>-balance N<jats:sub>2<\/jats:sub> for 5 min; P &gt; 0.05). Furthermore, the apneic response evoked by stimulating bronchopulmonary C fibers (PCFs) with right atrial injection of capsaicin (5 \u03bcg) was markedly increased in the Ova-sensitized group (5.02 \u00b1 1.56 s), compared with the control group (1.82 \u00b1 0.45 s; P &lt; 0.05). These results suggest that Ova sensitization induces a DVH in guinea pigs, which probably results from an attenuation of the carotid chemoreceptor-mediated ventilatory excitation and an enhancement of the PCF-mediated ventilatory inhibition. <\/jats:p>","DOI":"10.1152\/japplphysiol.00613.2005","type":"journal-article","created":{"date-parts":[[2005,7,16]],"date-time":"2005-07-16T00:32:42Z","timestamp":1121473962000},"page":"1782-1788","source":"Crossref","is-referenced-by-count":9,"title":["Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs"],"prefix":"10.1152","volume":"99","author":[{"given":"Fadi","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongrong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-Yuan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018740"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(82)90038-0"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1097\/00063110-200209000-00004"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.73.5.667"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118132"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1977.tb01481.x"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015072"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197002192820801"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.041002.131103"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.3.1385"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-199911000-00003"},{"key":"R12","unstructured":"Hirshman CA and Downes H. 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