{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T07:23:33Z","timestamp":1775287413165,"version":"3.50.1"},"reference-count":30,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881371450201901"],"award-info":[{"award-number":["88881371450201901"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/210.910\/2016"],"award-info":[{"award-number":["E-26\/210.910\/2016"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/010.0014488\/2019"],"award-info":[{"award-number":["E-26\/010.0014488\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["421067\/2016-0"],"award-info":[{"award-number":["421067\/2016-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:p> In a rat model of Escherichia coli lipopolysaccharide-induced mild\/moderate acute respiratory distress syndrome, a gradual PEEP increase (shorter adaptation time) effectively mitigated histological lung injury and biomarker release associated with lung inflammation, damage to epithelial cells, endothelial cells, and the extracellular matrix compared with an abrupt increase in PEEP. A more gradual PEEP increase (longer adaptation time) decreased lung damage, pulmonary vessel compression, and pulmonary arterial pressure. <\/jats:p>","DOI":"10.1152\/japplphysiol.00613.2021","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T17:01:25Z","timestamp":1640278885000},"page":"375-387","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["A more gradual positive end-expiratory pressure increase reduces lung damage and improves cardiac function in experimental acute respiratory distress syndrome"],"prefix":"10.1152","volume":"132","author":[{"given":"Marcos V. S.","family":"Fernandes","sequence":"first","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazareth N.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niteroi, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathane S.","family":"Felix","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00edsa H. A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana S.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina F.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina G. M.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L.","family":"Capelozzi","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Pelosi","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy"},{"name":"San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-4949","authenticated-orcid":true,"given":"Pedro L.","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-2076","authenticated-orcid":true,"given":"John J.","family":"Marini","sequence":"additional","affiliation":[{"name":"Regions Hospital and University of Minnesota, Minneapolis\/Saint Paul, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-7136","authenticated-orcid":true,"given":"Patricia R. M.","family":"Rocco","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000295309.69123.AE"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001718"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2406-9"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004416"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000147445.73344.3A"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318206d69a"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318206d69a"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002630"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00861.2015"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1186\/cc3877"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00931.2015"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610868104"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-019-0226-5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000716"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.1.25"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002143"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-15-56"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003060"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-19"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2465"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3522"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00110.2005"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00010.2011"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.6.3121"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201509-1878OC"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbbm.2006.11.008"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0210ST"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00613.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T17:25:31Z","timestamp":1643217931000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00613.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2,1]]}},"alternative-id":["10.1152\/japplphysiol.00613.2021"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00613.2021","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,1]]},"assertion":[{"value":"2021-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}