{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T07:17:10Z","timestamp":1649056630944},"reference-count":31,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p> We tested the hypothesis that, during acute glucose-induced hyperosmolality, the brain shrinks less than predicted on the basis of an ideal osmometer and that brain volume regulation is present in fetuses, premature and newborn lambs. Brain water responses to glucose-induced hyperosmolality were measured in the cerebral cortex, cerebellum, and medulla of fetuses at 60% of gestation, premature ventilated lambs at 90% of gestation, newborn lambs, and adult sheep. After exposure of the sheep to increases in osmolality with glucose plus NaCl, brain water and electrolytes were measured. The ideal osmometer is a system in which impermeable solutes do not enter or leave in response to an osmotic stress. In the absence of volume regulation, brain solute remains constant as osmolality changes. The osmotically active solute demonstrated direct linear correlations with plasma osmolality in the cerebral cortex of the fetuses at 60% of gestation ( r = 0.72, n = 24, P = 0.0001), premature lambs ( r = 0.58, n = 22, P = 0.005), newborn lambs ( r = 0.57, n = 24, P = 0.004), and adult sheep ( r = 0.70, n = 18, P = 0.001). Similar findings were observed in the cerebellum and medulla. Increases in the quantity of osmotically active solute over the range of plasma osmolalities indicate that volume regulation was present in the brain regions of the fetuses, premature lambs, newborn lambs, and adult sheep during glucose-induced hyperosmolality. We conclude that, during glucose-induced hyperosmolality, the brain shrinks less than predicted on the basis of an ideal osmometer and exhibits volume regulation in fetuses at 60% of gestation, premature lambs, newborn lambs, and adult sheep. <\/jats:p>","DOI":"10.1152\/japplphysiol.00617.2003","type":"journal-article","created":{"date-parts":[[2004,1,31]],"date-time":"2004-01-31T01:14:01Z","timestamp":1075511641000},"page":"553-560","source":"Crossref","is-referenced-by-count":2,"title":["Regulation of brain water during acute glucose-induced hyperosmolality in ovine fetuses, lambs, and adults"],"prefix":"10.1152","volume":"96","author":[{"given":"Barbara S.","family":"Stonestreet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine H.","family":"Petersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazyna B.","family":"Sadowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford S.","family":"Patlak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1993.264.6.R1164"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(95)90077-2"},{"key":"REF3","unstructured":"Bradbury MWB and Cserr HF. Drainage of Cerebral Interstitial Fluid and of Cerebrospinal Fluid Into Lymphatics. Amsterdam: Elsevier, 1985."},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1985.249.5.E454"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1987.253.3.F522"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1987.253.3.F530"},{"key":"REF7","unstructured":"Cserr HF and Patlak CS. Regulation of brain volume under isosmotic and anisosmotic conditions. In: Advances in Comparative and Environmental Physiology, edited by Gilles R, Hoffmann EK, and Bolis L. Berlin: Springer-Verlag, 1991, p. 61-80."},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-3-1530"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1976.11714420"},{"key":"REF10","unstructured":"Fenstermacher JD. Volume Regulation of the Central Nervous System. New York: Raven, 1984."},{"key":"REF11","unstructured":"Grylack LJ, Chu SS, and Scanlon JW. Use of intravenous fluids before cesarean section: effects on perinatal glucose, insulin, and sodium homeostasis. Obstet Gynecol 63: 654-658, 1984."},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1989.257.6.F1108"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.3109\/00016349609054708"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2920-0_11"},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402680204"},{"key":"REF16","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(99)00160-9"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)31211-9"},{"key":"REF18","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)34968-9"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1159\/000242795"},{"key":"REF20","unstructured":"Otto Buczkowska E, Szirer G, and Jarosz-Chobot P. Glucose homeostasis in children. I. Regulation of blood glucose. Przegl Lek 58: 20-24, 2001."},{"key":"REF21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-445X.1999.tb00085.x"},{"key":"REF22","doi-asserted-by":"publisher","DOI":"10.1159\/000010293"},{"key":"REF23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.4.H1098"},{"key":"REF24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.5.1672"},{"key":"REF25","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00923.2002"},{"key":"REF26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1996.271.6.R1594"},{"key":"REF27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.2.R468"},{"key":"REF28","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198911000-00024"},{"key":"REF29","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00650-F"},{"key":"REF30","doi-asserted-by":"publisher","DOI":"10.1053\/sp.2000.6361"},{"key":"REF31","unstructured":"Wu PY. Infant of diabetic mother: a continuing challenge for perinatal-neonatal medicine. 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