{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:59:53Z","timestamp":1785437993212,"version":"3.56.0"},"reference-count":64,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100000023","name":"Government of Canada","doi-asserted-by":"publisher","award":["RGPIN-2016-04915"],"award-info":[{"award-number":["RGPIN-2016-04915"]}],"id":[{"id":"10.13039\/501100000023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2216548"],"award-info":[{"award-number":["2216548"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>\n                    Understanding the role of ancestry in the regulation of ventilatory and renal homeostasis is key to interpreting high-altitude acclimatization and adaptation. We compared unacclimatized lowlanders (LL) and Tibetan highlanders (TH; Sherpa) at 1,400 m. TH had significantly lower Pco\n                    <jats:sub>2<\/jats:sub>\n                    and [HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ], suggesting a distinct respiratory and blood acid-base set point. These results highlight intrinsic respiratory and renal integration in TH, revealing population-level physiological differences independent of hypoxic stress, likely shaped by developmental or genetic adaptation.\n                  <\/jats:p>","DOI":"10.1152\/japplphysiol.00619.2025","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T14:59:49Z","timestamp":1758207589000},"page":"1064-1072","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["No altitude required: differential ventilatory and blood acid-base homeostasis between unacclimatized lowlanders and Tibetan highlanders at 1,400 m"],"prefix":"10.1152","volume":"139","author":[{"given":"Nicole V.","family":"Bushfield","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04evsam41","id-type":"ROR","asserted-by":"publisher"}],"name":"Mount Royal University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole A.","family":"Johnson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04evsam41","id-type":"ROR","asserted-by":"publisher"}],"name":"Mount Royal University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Dickenson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04evsam41","id-type":"ROR","asserted-by":"publisher"}],"name":"Mount Royal University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4097-7382","authenticated-orcid":false,"given":"Benjamin W. 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