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This lack of treatment may be partially due to the relative dearth of literature on mechanisms occurring within the muscle before the onset of muscle wasting. Therefore, the purpose of this review is to compile the current scientific literature on mechanisms contributing to the development and progression of cancer cachexia, including protein turnover, inflammatory signaling, and mitochondrial dysfunction. We define \u201cdevelopment\u201d as changes in cell function occurring before the onset of cachexia and \u201cprogression\u201d as alterations to cell function that coincide with the exacerbation of muscle wasting. Overall, the current literature suggests that multiple aspects of cellular function, such as protein turnover, inflammatory signaling, and mitochondrial quality, are altered before the onset of muscle loss during cancer cachexia and clearly highlights the need to study more thoroughly the developmental stages of cachexia. The studying of these early aberrations will allow for the development of effective therapeutics to prevent the onset of cachexia and improve health outcomes in cancer patients.<\/jats:p>","DOI":"10.1152\/japplphysiol.00622.2019","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T19:41:43Z","timestamp":1573760503000},"page":"25-41","source":"Crossref","is-referenced-by-count":26,"title":["Muscle alterations in the development and progression of cancer-induced muscle atrophy: a review"],"prefix":"10.1152","volume":"128","author":[{"given":"Megan E.","family":"Rosa-Caldwell","sequence":"first","affiliation":[{"name":"Integrative Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Human Health Performance and Recreation, University of Arkansas, Fayetteville, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis K.","family":"Fix","sequence":"additional","affiliation":[{"name":"Molecular Medicine 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