{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:31:45Z","timestamp":1791160305714,"version":"4.1.0"},"reference-count":20,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p> We have developed a discrete multisegmental model describing the coupling between inspiratory flow and nasal wall distensibility. This model is composed of 14 individualized compliant elements, each with its own relationship between cross-sectional area and transmural pressure. Conceptually, this model is based on flow limitation induced by the narrowing of duct due to collapsing pressure. For a given inspiratory pressure and for a given compliance distribution, this model predicts the area profile and inspiratory flow. Acoustic rhinometry and posterior rhinomanometry were used to determine the initial geometric area and mechanical characteristics of each element. The proposed model, used under steady-state conditions, is able to simulate the pressure-flow relationship observed in vivo under normal conditions (4 subjects) and under pathological conditions (4 vasomotor rhinitis and 3 valve syndrome subjects). Our results suggest that nasal wall compliance is an essential parameter to understand the nasal inspiratory flow limitation phenomenon and the associated increase of resistance that is well known to physiologists. By predicting the functional pressure-flow relationship, this model could be a useful tool for the clinician to evaluate the potential effects of treatments. <\/jats:p>","DOI":"10.1152\/japplphysiol.00625.2004","type":"journal-article","created":{"date-parts":[[2004,8,28]],"date-time":"2004-08-28T01:24:57Z","timestamp":1093656297000},"page":"288-295","source":"Crossref","is-referenced-by-count":42,"title":["Inspiratory flow in the nose: a model coupling flow and vasoerectile tissue distensibility"],"prefix":"10.1152","volume":"98","author":[{"given":"Redouane","family":"Fodil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Brugel-Ribere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Croce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Sbirlea-Apiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Larger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Papon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Delclaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Coste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Isabey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947007900308"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00085.2002"},{"key":"R3","unstructured":"Clement PA. Committee report on standardization of rhinomanometry. Rhinology 22: 151\u2013155, 1984."},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1159\/000275707"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.14612789"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1089\/08942680152007936"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9709019"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02510972"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.1.295"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.5.1589"},{"key":"R11","unstructured":"Hirschberg A, Roithmann R, Parikh S, Miljeteig H, and Cole P. The airflow resistance profile of healthy nasal cavities. Rhinology 33: 10\u201313, 1995."},{"key":"R12","unstructured":"Isono S and Remmers JE. Anatomy and physiology of upper airway obstruction. In: Principles and Practice of Sleep Medicine, edited by Kryger MH, Roth T, and Dement W. Philadelphia, PA: Saunders, 1993, p. 642\u2013656."},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.4.1319"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.2.547"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.2.630"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1115\/1.2895487"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890240050011"},{"key":"R18","unstructured":"Proctor DF. The upper airways. I. Nasal physiology and defense of the lungs. Am Rev Respir Dis 115: 97\u2013129, 1977."},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.2500\/105065897781286016"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Widdicombe J. Microvascular anatomy of the nose. Allergy 52: 7\u201311, 1997.","DOI":"10.1111\/j.1398-9995.1997.tb04877.x"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00625.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T20:13:21Z","timestamp":1567973601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00625.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1152\/japplphysiol.00625.2004"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00625.2004","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}