{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T22:32:29Z","timestamp":1772145149964,"version":"3.50.1"},"reference-count":46,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p> We have previously demonstrated that a transient exposure to hyperbaric oxygen (HBO) attenuated the neuronal injury after neonatal hypoxia-ischemia. This study was undertaken to determine whether HBO offers this neuroprotection by reducing apoptosis in injured brain tissue. Seven-day-old rat pups were subjected to unilateral carotid artery ligation followed by 2 h of hypoxia (8% oxygen). Apoptotic cell death was examined in the injured cortex and hippocampus tissue. Caspase-3 expression and activity increased at 18 and 24 h after the hypoxia-ischemia insult. At 18-48 h, poly(ADP-ribose) polymerase (PARP) cleavage occurred, which reduced the band at 116 kDa and enhanced the band at 85 kDa. There was a time-dependent increase in the number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL)-positive cells. A single HBO treatment (100% oxygen, 3 ATA for 1 h) 1 h after hypoxia reduced the enhanced caspase-3 expression and activity, attenuated the PARP cleavage, and decreased the number of TUNEL-positive cells observed in the cortex and hippocampus. These results suggest that the neuroprotective effect of HBO is at least partially mediated by the reduction of apoptosis. <\/jats:p>","DOI":"10.1152\/japplphysiol.00630.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:47:13Z","timestamp":1425415633000},"page":"2072-2080","source":"Crossref","is-referenced-by-count":62,"title":["Effect of hyperbaric oxygen on apoptosis in neonatal hypoxia-ischemia rat model"],"prefix":"10.1152","volume":"95","author":[{"given":"John W.","family":"Calvert","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana 71130"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changman","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana 71130"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Nanda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana 71130"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana 71130"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200111000-00010"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02722933"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2407::AID-CNCR33>3.0.CO;2-Z"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200112000-00003"},{"key":"REF5","unstructured":"Baidin SA, Ivanov OP, Ivanov MG, Berendeev SN, and Gorinova SV. 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