{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:01:00Z","timestamp":1789696860594,"version":"4.0.1"},"reference-count":0,"publisher":"American Physiological Society","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL136601"],"award-info":[{"award-number":["R01HL136601"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["835833"],"award-info":[{"award-number":["835833"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"abstract":"<jats:p> Interest in ketones as a cardiac 'super fuel' has grown significantly following reports of a marked increase in cardiac output following exogenous ketone administration in heart failure. However, the extent to which this increase in cardiac output is related to changes in cardiac contractility, and dependent on the presence of heart failure, remains incompletely understood. Therefore, we performed a randomized, double-blind, placebo-controlled study of oral ketone ester in young healthy volunteers. Baseline cardiac magnetic resonance imaging was performed and repeated every 15 minutes for 60 minutes after ketone and placebo ingestion to assess changes in left ventricular function. As expected, circulating \u03b2-hydroxybutyrate increased rapidly after ketone ingestion, but did not change with placebo (interaction: p&lt;0.001). Consistent with prior investigations, ketone ingestion resulted in an average 1 L\/min increase in cardiac output after 60 minutes that did not occur with placebo (interaction: p=0.026). This increase in cardiac output was primarily driven by an increase in heart rate after ketone ingestion (interaction: p=0.018), with only a modest increase in stroke volume (interaction: p=0.037). Changes in left ventricular strain and twist mechanics were limited. Taken together, the increase in cardiac output following an acute elevation in circulating \u03b2-hydroxybutyrate is primarily driven by changes in cardiac chronotropy, with minimal inotropic contribution. <\/jats:p>","DOI":"10.1152\/japplphysiol.00630.2023","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:00:26Z","timestamp":1698307226000},"update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Acute effects of \u03b2-hydroxybutyrate on left ventricular function in young, healthy adults"],"prefix":"10.1152","author":[{"given":"Andrew P.","family":"Oneglia","sequence":"first","affiliation":[{"name":"Department of Kinesiology, The University of Texas at Arlington, Arlington, TX, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin E.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Applied Clinical Research, The University of Texas Southwestern Medical Center, Dallas, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisha J.","family":"Cipher","sequence":"additional","affiliation":[{"name":"Graduate Nursing, The University of Texas at Arlington, Arlington, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"Zaha","sequence":"additional","affiliation":[{"name":"Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Applied Physiology and Advanced Imaging Laboratory, The University of Texas at Arlington, Arlington, TX, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","published-online":{"date-parts":[[2023,10,26]]},"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00630.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T19:00:25Z","timestamp":1699556425000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00630.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,26]]},"references-count":0,"alternative-id":["10.1152\/japplphysiol.00630.2023"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00630.2023","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,26]]},"assertion":[{"value":"2023-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"japplphysiol.00630.2023"}}