{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T16:05:13Z","timestamp":1749571513765,"version":"3.40.5"},"reference-count":53,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p> Collegiate athletes are exposed to varying levels of academic and physical stressors, placing them at increased risk for stress-activated latent viral infections. However, the impact of allostatic stress load on the immune response to maximal exercise in athletes remains largely unknown. This study examined the effects of a 7-mo training period and cytomegalovirus (CMV) serostatus on immune cell response to high-intensity swim tests within a group of collegiate swimmers. Samples were collected from 15 National Collegiate Athletic Association Division I swimmers (9 men, 6 women: 19.87\u2009\u00b1\u20090.64 yr) before and after exhaustive in-pool swims at 2 time points (V<jats:sub>1<\/jats:sub>: immediately post-season 1 and V<jats:sub>3<\/jats:sub>: beginning of season 2). An additional off-season (V<jats:sub>2<\/jats:sub>) time point was collected in a subset of 9 swimmers. Natural killer (NK) cell, B cell, and T cells were quantified by flow cytometry. Linear mixed models were used to determine the effects of exercise, time point, and CMV serostatus (\u03b1\u2009=\u20090.05). Resting senescent CD8+ T cells were higher in CMV-seropositive participants at V<jats:sub>3<\/jats:sub> ( P = 0.005). CMV-seronegative participants had a decrease in resting senescent CD8+ T cells from V<jats:sub>1<\/jats:sub> to V<jats:sub>3<\/jats:sub> ( P = 0.021). After acute exercise, CMV-seropositive participants had lower na\u00efve CD8+ T cells ( P &lt; 0.001) and higher senescent CD8+ T cells ( P &lt; 0.001). Increased cumulative stress levels did not appear to affect B-cell and NK-cell compartments. Immune response to exercise was impacted by CMV serostatus and allostatic stress load. Young CMV-seropositive athletes exposed to elevated stressors should be monitored to determine long-term effects of training and academic stressors. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY Allostatic stress load is associated with impaired immune response to maximal exercise in cytomegalovirus (CMV)-seropositive subjects but not in CMV-seronegative young healthy adults. <\/jats:p>","DOI":"10.1152\/japplphysiol.00646.2019","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T11:34:51Z","timestamp":1574854491000},"page":"178-188","source":"Crossref","is-referenced-by-count":9,"title":["Allostatic stress load and CMV serostatus impact immune response to maximal exercise in collegiate swimmers"],"prefix":"10.1152","volume":"128","author":[{"given":"Bailey","family":"Theall","sequence":"first","affiliation":[{"name":"School of Kinesiology, Louisiana State University, Huey P. 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