{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:58:56Z","timestamp":1740139136040,"version":"3.37.3"},"reference-count":48,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["201503MOP-342412-MOVCEEA"],"award-info":[{"award-number":["201503MOP-342412-MOVCEEA"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p> Post-cardiac event cognitive impairment is common and exercise-based rehabilitation may be an effective intervention to mitigate cognitive decline. Microvascular damage due to high blood pressure pulsatility entering the brain is the putative mechanism of vascular dementia. Whether patients with ischemic heart disease exhibit lower cerebrovascular compliance, and if cardiac rehabilitation can improve cerebrovascular compliance is unknown. We observed that patients with ischemic heart disease have paradoxically higher cerebrovascular compliance, which is not affected by cardiac rehabilitation. <\/jats:p>","DOI":"10.1152\/japplphysiol.00654.2022","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T18:00:17Z","timestamp":1692900017000},"page":"753-762","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of ischemic heart disease and cardiac rehabilitation on cerebrovascular compliance"],"prefix":"10.1152","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-0013","authenticated-orcid":false,"given":"Geoff B.","family":"Coombs","sequence":"first","affiliation":[{"name":"School of Kinesiology, University of Western Ontario, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baraa K.","family":"Al-Khazraji","sequence":"additional","affiliation":[{"name":"School of Kinesiology, University of Western Ontario, London, Ontario, Canada"},{"name":"Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-1351","authenticated-orcid":false,"given":"Neville","family":"Suskin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-5979","authenticated-orcid":false,"given":"J. Kevin","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"School of Kinesiology, University of Western Ontario, London, Ontario, Canada"},{"name":"Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.983536"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2017.02.005"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8030290"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184244"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.09.007"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.10"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcz041"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.513176"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr253"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a43e1c"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-2115(98)00320-0"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-5629(98)00024-6"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00940"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00035.2021"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00272.2020"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000742"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140030"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.06.104"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.12.057"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201456"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00057.2020"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00224"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14212"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.physio.2011.11.003"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"volume-title":"Canadian Guidelines for Cardiac Rehabilitation and Cardiovascular Disease Prevention: Translating Knowledge into Action","year":"2009","author":"Stone J","key":"B27"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.01.011"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.037937"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200910218"},{"volume-title":"The Physics of Coronary Blood Flow","year":"2005","author":"Zamir M","key":"B31"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01880.x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.20.1.45"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.26.6.1014"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.10.2.133"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1113\/EP089533"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12905"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00361.2016"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1177\/1179546819839411"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00880.2020"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3233\/BPL-180075"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.19"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.625418"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X14556695"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00230.2021"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73658-0"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2022.01.007"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015634"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00654.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T12:38:07Z","timestamp":1695299887000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00654.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10,1]]}},"alternative-id":["10.1152\/japplphysiol.00654.2022"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00654.2022","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"type":"print","value":"8750-7587"},{"type":"electronic","value":"1522-1601"}],"subject":[],"published":{"date-parts":[[2023,10,1]]},"assertion":[{"value":"2022-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}