{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:06:23Z","timestamp":1779260783020,"version":"3.51.4"},"reference-count":45,"publisher":"American Physiological Society","issue":"6","funder":[{"name":"Natioanl Sciences and Engineering Research Council","award":["RGPIN-2015-04632"],"award-info":[{"award-number":["RGPIN-2015-04632"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:p> We reported that supplementation with green tea extract (GTE) lowered the glycemic response to an oral glucose load following exercise, but via an unknown mechanism (Martin BJ, MacInnis MJ, Gillen JB, Skelly LE, Gibala MJ. Appl Physiol Nutr Metab 41: 1057\u20131063, 2016. Here we examined the effect of supplementation with GTE on plasma glucose kinetics on ingestion of a glucose beverage during exercise recovery. Eleven healthy, sedentary men (21 \u00b1 2 yr old; body mass index = 23 \u00b1 4 kg\/m<jats:sup>2<\/jats:sup>, peak O<jats:sub>2<\/jats:sub> uptake = 38 \u00b1 7 ml\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>; means \u00b1 SD) ingested GTE (350 mg) or placebo (PLA) thrice daily for 7 days in a double-blind, crossover design. In the fasted state, a primed constant infusion of [U-<jats:sup>13<\/jats:sup>C<jats:sub>6<\/jats:sub>]glucose was started, and 1 h later, subjects performed a graded exercise test (25 W\/3 min) on a cycle ergometer. Immediately postexercise, subjects ingested a 75-g glucose beverage containing 2 g of [6,6-<jats:sup>2<\/jats:sup>H<jats:sub>2<\/jats:sub>]glucose, and blood samples were collected every 10 min for 3 h of recovery. The rate of carbohydrate oxidation was lower during exercise after GTE vs. PLA (1.26 \u00b1 0.34 vs. 1.48 \u00b1 0.51 g\/min, P = 0.04). Glucose area under the curve (AUC) was not different between treatments after drink ingestion (GTE = 1,067 \u00b1 133 vs. PLA = 1,052 \u00b1 91 mM\/180 min, P = 0.91). Insulin AUC was lower after GTE vs. PLA (5,673 \u00b1 2,153 vs. 7,039 \u00b1 2,588 \u00b5IU\/180 min, P = 0.05), despite similar rates of glucose appearance (GTE = 0.42 \u00b1 0.16 vs. PLA = 0.43 \u00b1 0.13 g\/min, P = 0.74) and disappearance (GTE = 0.43 \u00b1 0.14 vs. PLA = 0.44 \u00b1 0.14 g\/min, P = 0.57). We conclude that short-term GTE supplementation did not affect glucose kinetics following ingestion of an oral glucose load postexercise; however, GTE was associated with attenuated insulinemia. These findings suggest GTE lowers the insulin required for a given glucose load during postexercise recovery, which warrants further mechanistic studies in humans. <\/jats:p>","DOI":"10.1152\/japplphysiol.00657.2016","type":"journal-article","created":{"date-parts":[[2016,10,8]],"date-time":"2016-10-08T01:40:31Z","timestamp":1475890831000},"page":"1282-1289","source":"Crossref","is-referenced-by-count":7,"title":["Green tea extract does not affect exogenous glucose appearance but reduces insulinemia with glucose ingestion in exercise recovery"],"prefix":"10.1152","volume":"121","author":[{"given":"Brian J.","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"McGlory","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"MacInnis","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K.","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Gibala","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200201000-00015"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500097"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520220126"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.S212"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2012.05.007"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2007.10719627"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508047727"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2006.10719518"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.05.003"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2549"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.19.6.624"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.6.1040"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200206"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.2.628"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2174\/157339913804143225"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1480"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC4502_13"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.06.017"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3945\/an.112.003269"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.01.044"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.11.1663"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200500109"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.06.011"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/nu8010017"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1021\/jf0006832"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(91)80494-W"},{"key":"B27","first-page":"1025","volume":"11","author":"Lee MJ","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.03.036"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.5.572"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2016-0169"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.2013-0202"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/56.5.848"},{"key":"B34","first-page":"25","volume":"24","author":"Proietto J","year":"1990","journal-title":"Horm Metab Res Suppl"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31827dd9d4"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000205"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181bcab6c"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.01.006"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2337\/diab.17.7.415"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-012-9448-z"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-4-18"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.09.128"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.3.778"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31815f256f"},{"key":"B45","volume-title":"Radioactive and Stable Isotopes in Biomedicine: Principles and Practices of Kinetic Analysis","author":"Wolfe RR","year":"1992"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00657.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T21:32:22Z","timestamp":1567978342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00657.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12,1]]}},"alternative-id":["10.1152\/japplphysiol.00657.2016"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00657.2016","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,1]]}}}