{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:53:32Z","timestamp":1790906012591,"version":"4.1.0"},"reference-count":56,"publisher":"American Physiological Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:p>Purpose: the relationship between physical activity and airway health in children is not well understood. The purpose of this study was to determine whether 8 wk of high-intensity exercise training would improve airway responsiveness in prepubescent, nonasthmatic, inactive children. Methods: 16 healthy, prepubescent children were randomized [training group (TrG) n = 8, control group (ConG) n = 8]. Prior to and following 8 wk of training (or no training), children completed pulmonary function tests (PFTs): forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>), forced vital capacity (FVC), forced expiratory flow at 25\u201375% of vital capacity (FEF<jats:sub>25\u201375<\/jats:sub>), and exhaled nitric oxide (FENO). Children completed an incremental cycle V\u0307o<jats:sub>2max<\/jats:sub>test, eucapnic voluntary hyperventilation (EVH), anthropometric tests, and blood tests to determine fasting blood glucose, total cholesterol, HDL, LDL, and triglycerides. Body fat percentage was determined using dual-energy X-ray absorptiometry pretraining and bioelectrical impedance pre- and posttraining. Results: there were no differences ( P &gt; 0.05) in anthropometric measures or PFTs between TrG and ConG at baseline. In the TrG, there was a significant increase in V\u0307o<jats:sub>2max<\/jats:sub>(\u223c24%) and a decrease in total cholesterol (\u223c13%) and LDL cholesterol (\u223c35%) following training. There were improvements ( P &lt; 0.05) in \u0394FEV<jats:sub>1<\/jats:sub>both postexercise (pre: \u22127.60 \u00b1 2.10%, post: \u22121.10 \u00b1 1.80%) and post-EVH (pre: \u22126.71 \u00b1 2.21%, post: \u22121.41 \u00b1 1.58%) with training. The \u0394FEF<jats:sub>25\u201375<\/jats:sub>pre-post exercise also improved with training (pre: \u221216.10 \u00b1 2.10%, post: \u22126.80 \u00b1 1.80%; P &lt; 0.05). Lower baseline body fat percentages were associated with greater improvements in pre-post exercise \u0394FEV<jats:sub>1<\/jats:sub>following training ( r = \u22120.80, P &lt; 0.05). Conclusion: these results suggest that in nonasthmatic prepubescent children, inactivity negatively impacts airway responsiveness, which can be improved with high-intensity training. Excess adiposity, however, may constrain these improvements.<\/jats:p>","DOI":"10.1152\/japplphysiol.00663.2011","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T05:35:58Z","timestamp":1326432958000},"page":"1174-1183","source":"Crossref","is-referenced-by-count":22,"title":["High-intensity training improves airway responsiveness in inactive nonasthmatic children: evidence from a randomized controlled trial"],"prefix":"10.1152","volume":"112","author":[{"given":"Sara K.","family":"Rosenkranz","sequence":"first","affiliation":[{"name":"Departments of Kinesiology and"},{"name":"Human Nutrition, Kansas State University, Manhattan, Kansas;"},{"name":"Department of General Practice,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Rosenkranz","sequence":"additional","affiliation":[{"name":"Human Nutrition, Kansas State University, Manhattan, Kansas;"},{"name":"School of Science and Health, University of Western 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