{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:11:16Z","timestamp":1770833476902,"version":"3.50.1"},"reference-count":42,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K22796"],"award-info":[{"award-number":["19K22796"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K17730"],"award-info":[{"award-number":["22K17730"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:p> This study is the first to show marathon running transiently increases plasma XOR activity and levels of purine degradation products (hypoxanthine, xanthine, and uric acid), and further to demonstrate that activated plasma XOR may contribute to marathon-induced elevations in biomarkers of AKI. These findings significantly extend our prior knowledge of the purine metabolic pathway and several AKI biomarkers under strenuous exercise conditions. <\/jats:p>","DOI":"10.1152\/japplphysiol.00669.2021","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T11:12:25Z","timestamp":1652958745000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Xanthine oxidoreductase activity in marathon runners: potential implications for marathon-induced acute kidney injury"],"prefix":"10.1152","volume":"133","author":[{"given":"Keisei","family":"Kosaki","sequence":"first","affiliation":[{"name":"Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Kumamoto","sequence":"additional","affiliation":[{"name":"Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Tokinoya","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan"},{"name":"Graduate School of Human Health Science, Tokyo Metropolitan University, Tokyo, Japan"},{"name":"Japan Society for the Promotion of Science, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan"},{"name":"Department of Clinical Laboratory Science, Faculty of Health Sciences, Tsukuba International University, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4515-9504","authenticated-orcid":true,"given":"Takayo","family":"Murase","sequence":"additional","affiliation":[{"name":"Sanwa Kagaku Kenkyusho Co., Ltd., Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seigo","family":"Akari","sequence":"additional","affiliation":[{"name":"Sanwa Kagaku Kenkyusho Co., Ltd., Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Sanwa Kagaku Kenkyusho Co., Ltd., Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"Nabekura","sequence":"additional","affiliation":[{"name":"Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Takekoshi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1642-4644","authenticated-orcid":true,"given":"Seiji","family":"Maeda","sequence":"additional","affiliation":[{"name":"Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan"},{"name":"Faculty of Sport Sciences, Waseda University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.023"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn163"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-305242"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-015-0007-6"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.01.045"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01354.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13618"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fspor.2019.00071"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-014-1210-x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)77283-9"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.05.022"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.10.006"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1159\/000441091"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1992.tb09465.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-017-0536-x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1993.tb09636.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1991.tb09157.x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2001.24197"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1968.03140030033008"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.10.033"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.483"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/cc5713"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22202"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00378.2020"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1309\/14TY-2TDJ-1X0Y-1V6V"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12561"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.17-101"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165673"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.05.020"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.05.038"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007010097"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-005-9047-9"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1228-4"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00581.2007"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00517.2015"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1892\/0891-6640(2006)20[228:eoatot"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ18-0127"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.080564"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.08.007"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00568.2012"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1220733"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00669.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T20:26:16Z","timestamp":1655929576000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00669.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7,1]]}},"alternative-id":["10.1152\/japplphysiol.00669.2021"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00669.2021","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,1]]},"assertion":[{"value":"2021-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}