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Novel histological findings by one of the team, Javier Arias-Stella, indicated that hypoxia-induced thickening of the pulmonary arteriolar walls was the primary cause of the elevated pressure. Because the hypertension was not promptly reversed by vasodilators (oxygen inhalation or acetylcholine infusion), they found it differed from acute hypoxic pulmonary vasoconstriction. The team's other novel findings included a delay in the normal fall in pulmonary vascular resistance after birth and, in adults, a lack of vasodilation with muscular exercise. Furthermore, the altitude-related pulmonary hypertension resolved over time at sea level. <\/jats:p>","DOI":"10.1152\/japplphysiol.00677.2004","type":"journal-article","created":{"date-parts":[[2004,12,11]],"date-time":"2004-12-11T15:17:36Z","timestamp":1102778256000},"page":"384-389","source":"Crossref","is-referenced-by-count":22,"title":["Insights by Peruvian scientists into the pathogenesis of human chronic hypoxic pulmonary hypertension"],"prefix":"10.1152","volume":"98","author":[{"given":"John T.","family":"Reeves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Grover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","unstructured":"Arias-Stella J and Kruger H. Pathology of high altitude pulmonary edema. Arch Pathol 76: 147\u2013157, 1963."},{"key":"R2","unstructured":"Arias-Stella J and Recavarren S. 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