{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:51:04Z","timestamp":1773967864148,"version":"3.50.1"},"reference-count":26,"publisher":"American Physiological Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:p>Measurements of left ventricular pressure (LVP) in conscious freely moving animals are uncommon, yet could offer considerable opportunity for understanding cardiovascular disease progression and treatment. The aim of this study was to develop surgical methods and validate the measurements of a new high-fidelity, solid-state pressure-sensor telemetry device for chronically measuring LVP and dP\/d t in rats. The pressure-sensor catheter tip (2-Fr) was inserted into the left ventricular chamber through the apex of the heart, and the telemeter body was implanted in the abdomen. Data were measured up to 85 days after implant. The average daytime dP\/d t max was 9,444 \u00b1 363 mmHg\/s, ranging from 7,870 to 10,558 mmHg\/s ( n = 7). A circadian variation in dP\/d t max and heart rate (HR) was observed with an average increase during the night phase in dP\/d t max of 918 \u00b1 84 mmHg\/s, and in HR of 38 \u00b1 3 bpm. The \u03b2-adrenergic-agonist isoproterenol, \u03b2<jats:sub>1<\/jats:sub>-adrenergic agonist dobutamine, Ca<jats:sup>2+<\/jats:sup>channel blocker verapamil, and the calcium sensitizer levosimendan were administered throughout the implant period, inducing dose-dependent time course changes and absolute changes in dP\/d t max of \u22126,000 to +13,000 mmHg\/s. The surgical methods and new technologies demonstrated long-term stability, sensitivity to circadian variation, and the ability to measure large drug-induced changes, validating this new solution for chronic measurement of LVP in conscious rats.<\/jats:p>","DOI":"10.1152\/japplphysiol.00683.2013","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T13:24:55Z","timestamp":1381497895000},"page":"1672-1682","source":"Crossref","is-referenced-by-count":13,"title":["Chronic measurement of left ventricular pressure in freely moving rats"],"prefix":"10.1152","volume":"115","author":[{"given":"Ellyce","family":"Stehlin","sequence":"first","affiliation":[{"name":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon C.","family":"Malpas","sequence":"additional","affiliation":[{"name":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;"},{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand,"},{"name":"Millar Inc, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Budgett","sequence":"additional","affiliation":[{"name":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;"},{"name":"Millar Inc, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn J.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"McCormick","sequence":"additional","affiliation":[{"name":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;"},{"name":"Millar Inc, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Whalley","sequence":"additional","affiliation":[{"name":"Faculty of Social and Health Sciences, Unitec, Auckland, New Zealand; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumin","family":"Fu","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Beil","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean F.","family":"Rigel","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah-Jane","family":"Guild","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand,"},{"name":"Millar Inc, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2009.03.006"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00105.2006"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.66.5.1400"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.114744"},{"key":"B5","author":"Data Sciences International","year":"2010","journal-title":"DSI Pressure Sensing Technologies in Small Animal Chronic Monitoring Applications, New Brigton, MN"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104469"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00139.2008"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.82.4.519"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.6.1422"},{"key":"B10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1161\/01.HYP.0000150857.39919.cb","volume":"45","author":"Kurtz TW","year":"2005","journal-title":"Hypertension"},{"key":"B11","volume-title":"Cardiac and Vascular Anesthesia: the requisites in anesthesiology","author":"Leung JM","year":"2004"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(75)90048-X"},{"key":"B13","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1440-1681.2010.05406.x","volume":"37","author":"McCormick D","year":"2010","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"B14","author":"Mensor Corporation","year":"2011","journal-title":"Mensor\/WIKA CPT 6100 Series Operating Instructions"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00393.2004"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.0765.2001"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2009.05.008"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.138"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.2.293"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.6.1424"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.167148"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.43.5.677"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8719(94)90003-5"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8719(92)90037-2"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8719(00)00126-X"},{"key":"B26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1152\/ajplegacy.1963.205.1.30","volume":"205","author":"Wallace AG","year":"1963","journal-title":"Am J Physiol"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00683.2013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T15:52:17Z","timestamp":1716047537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00683.2013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,1]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,12,1]]}},"alternative-id":["10.1152\/japplphysiol.00683.2013"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00683.2013","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,1]]}}}