{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:51:26Z","timestamp":1792799486674,"version":"4.5.0"},"reference-count":55,"publisher":"American Physiological Society","issue":"9","funder":[{"DOI":"10.13039\/501100001962","name":"World Anti-Doping Agency (l'Agence mondiale antidopage)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001962","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Medical Research Council (MRC)"},{"name":"Heart Lung Foundation"},{"name":"Vardal Foundation"},{"name":"Stockholm County Council Research Funds","id":[{"id":"https:\/\/ror.org\/02zrae794","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Swedish Strategic Research Foundation"},{"name":"KI-SciLifeLab collaborations on Translational Medicine"},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet (KI)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:p>\n                    Release of bronchoactive mediators from mast cells during exercise hyperpnea is a key factor in the pathophysiology of exercise-induced bronchoconstriction (EIB). Our aim was to investigate the effect of a standard, single dose of an inhaled \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    -adrenoceptor agonist on mast cell activation in response to dry air hyperpnea in athletes with EIB. Twenty-seven athletes with EIB completed a randomized, double-blind, placebo-controlled, crossover study. Terbutaline (0.5 mg) or placebo was inhaled 15 min prior to 8 min of eucapnic voluntary hyperpnea (EVH) with dry air. Pre- and postbronchial challenge, urine samples were analyzed by enzyme immunoassay for 11\u03b2-prostaglandin F\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    (11\u03b2-PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    ). The maximum fall in forced expiratory volume in 1 s of 14 (12\u201320)% (median and interquartile range) following placebo was attenuated to 7 (5\u20139)% with the administration of terbutaline ( P &lt; 0.001). EVH caused a significant increase in 11\u03b2-PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    from 41 (27\u201357) ng\/mmol creatinine at baseline to 58 (43\u201372) ng\/mmol creatinine at its peak post-EVH following placebo ( P = 0.002). The rise in 11\u03b2-PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    was inhibited with administration of terbutaline: 39 (28\u201344) ng\/mmol creatinine at baseline vs. 40 (33\u201358) ng\/mmol creatinine at its peak post-EVH ( P = 0.118). These data provide novel in vivo evidence of mast cell stabilization following inhalation of a standard dose of terbutaline prior to bronchial provocation with EVH in athletes with EIB.\n                  <\/jats:p>","DOI":"10.1152\/japplphysiol.00700.2015","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T22:44:52Z","timestamp":1454625892000},"page":"1011-1017","source":"Crossref","is-referenced-by-count":11,"title":["A standard, single dose of inhaled terbutaline attenuates hyperpnea-induced bronchoconstriction and mast cell activation in athletes"],"prefix":"10.1152","volume":"120","author":[{"given":"A. J.","family":"Simpson","sequence":"first","affiliation":[{"name":"Centre for Human Performance, Exercise and Rehabilitation, College of Health and Life Sciences, Brunel University London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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