{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:10:46Z","timestamp":1780506646826,"version":"3.54.1"},"reference-count":55,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA)","doi-asserted-by":"publisher","award":["15SDG23290000"],"award-info":[{"award-number":["15SDG23290000"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS)","doi-asserted-by":"publisher","award":["26440260"],"award-info":[{"award-number":["26440260"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:p>Postural changes impair the ability of the cerebrovasculature to buffer against dynamic pressure fluctuations, but the mechanisms underlying this impairment have not been elucidated. We hypothesized that autoregulatory impairment may reflect the impact of static central volume shifts on hemodynamic factors other than arterial pressure (AP). In 14 young volunteers, we assessed the relation of fluctuations in cerebral blood flow (CBF) to those in AP, cardiac output, and CO<jats:sub>2<\/jats:sub>, during oscillatory lower body pressure (LBP) (\u00b120 mmHg at 0.01 and 0.06 Hz) at three static levels (\u221220, 0, and +20 mmHg). Static and dynamic changes in AP, cardiac output, and CO<jats:sub>2<\/jats:sub>explained over 70% of the variation in CBF fluctuations. However, their contributions were different across frequencies and levels: dynamic AP changes explained a substantial proportion of the variation in faster CBF fluctuations (partial R<jats:sup>2<\/jats:sup>\u2009=\u20090.75, standardized \u03b2\u2009=\u20090.83, P &lt; 0.01), whereas those in CO<jats:sub>2<\/jats:sub>explained the largest portion of the variation in slow fluctuations (partial R<jats:sup>2<\/jats:sup>\u2009=\u20090.43, \u03b2\u2009=\u20090.51, P &lt; 0.01). There was, however, a major contribution of slow dynamic AP changes during negative (\u03b2\u2009=\u20090.43) but not neutral (\u03b2\u2009=\u20090.05) or positive (\u03b2\u2009=\u2009\u22120.07) LBP. This highlights the differences in contributions of systemic variables to dynamic and static autoregulation and has important implications for understanding orthostatic intolerance.<\/jats:p><jats:p>NEW &amp; NOTEWORTHY While fluctuations in blood pressure drive faster fluctuations in cerebral blood flow, overall level of CO<jats:sub>2<\/jats:sub>and the magnitude of its fluctuations, along with cardiac output, determine the magnitude of slow ones. The effect of slow blood pressure fluctuations on cerebrovascular responses becomes apparent only during pronounced central volume shifts (such as when standing). This underlines distinct but interacting contributions of static and dynamic changes in systemic hemodynamic variables to the cerebrovascular regulation.<\/jats:p>","DOI":"10.1152\/japplphysiol.00700.2017","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T01:20:44Z","timestamp":1507857644000},"page":"321-329","source":"Crossref","is-referenced-by-count":14,"title":["Relative contributions of systemic hemodynamic variables to cerebral autoregulation during orthostatic stress"],"prefix":"10.1152","volume":"124","author":[{"given":"Hisao","family":"Yoshida","sequence":"first","affiliation":[{"name":"Graduate School of Engineering, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason W.","family":"Hamner","sequence":"additional","affiliation":[{"name":"Cerebrovascular Research Laboratory, Spaulding Rehabilitation Hospital, Boston, 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