{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:45:33Z","timestamp":1792277133120,"version":"4.4.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2013,11,15]]},"abstract":"<jats:p>Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting \u03b2<jats:sub>2<\/jats:sub>-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15 min after inhaling 0.5 mg terbutaline or a matching placebo. Forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>) and urinary concentration of the club cell (Clara cell) protein 16 (CC16, a marker of airway epithelial perturbation) were measured before and up to 60 min after EVH. The maximum fall in FEV<jats:sub>1<\/jats:sub>of 17 \u00b1 8% (SD) on placebo was reduced to 8 \u00b1 5% following terbutaline ( P &lt; 0.001). Terbutaline gave bronchoprotection (i.e., post-EVH FEV<jats:sub>1<\/jats:sub>fall &lt;10%) to 22 (81%) athletes. EVH caused an increase in urinary excretion of CC16 in both conditions ( P &lt; 0.001), and terbutaline significantly reduced this rise (pre- to postchallenge CC16 increase 416 \u00b1 495 pg\/\u03bcmol creatinine after placebo vs. 315 \u00b1 523 pg\/\u03bcmol creatinine after terbutaline, P = 0.016). These results suggest that the inhalation of a single therapeutic dose of terbutaline offers significant protection against hyperpnoea-induced bronchoconstriction and attenuates acute airway epithelial perturbation in athletes.<\/jats:p>","DOI":"10.1152\/japplphysiol.00716.2013","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T01:02:24Z","timestamp":1379034144000},"page":"1450-1456","source":"Crossref","is-referenced-by-count":8,"title":["Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes"],"prefix":"10.1152","volume":"115","author":[{"given":"A. 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