{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:59:49Z","timestamp":1740139189690,"version":"3.37.3"},"reference-count":56,"publisher":"American Physiological Society","issue":"5","funder":[{"name":"Hungarian Basic Research Council","award":["GINOP-2.3.2-15-2016-00006"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00006"]}]},{"name":"Ministry for Innovation and Technology, Hungary","award":["UNKP-19-3"],"award-info":[{"award-number":["UNKP-19-3"]}]},{"name":"Ministry for Innovation and Technology, Hungary","award":["UNKP-20-3"],"award-info":[{"award-number":["UNKP-20-3"]}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["K138032"],"award-info":[{"award-number":["K138032"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["FK134274"],"award-info":[{"award-number":["FK134274"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:p> The present study examined the contributions of the lungs and chest wall to respiratory complications in a rat model of diabetes and clarified the effects of metformin on these changes. At low positive end-expiratory pressure, type 2 diabetes was linked to dysfunctional airway and lung tissue mechanics in relation with gas-exchange defects and collagen overexpression, whereas decreased tissue hysteresivity was manifested in the chest wall abnormalities. Metformin treated all adverse respiratory consequences of diabetes. <\/jats:p>","DOI":"10.1152\/japplphysiol.00724.2021","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T13:51:49Z","timestamp":1647525109000},"page":"1115-1124","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lung and chest wall mechanical properties in metformin-treated and untreated models of type 2 diabetes"],"prefix":"10.1152","volume":"132","author":[{"given":"\u00c1lmos","family":"Schranc","sequence":"first","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergely H.","family":"Fodor","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"S\u00fcdy","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary"},{"name":"Unit for Anesthesiological Investigations, Department of Acute Medicine, University of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bence","family":"Ball\u00f3k","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rich\u00e1rd","family":"Kulcs\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Tolnai","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barna","family":"Babik","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-9327","authenticated-orcid":true,"given":"Ferenc","family":"Pet\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01559-z"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221810017"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1556\/650.2018.31130"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061335"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/414813a"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v11.i8.351"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2016.0627"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03073.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017-00173"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.1.147"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01334-y"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00439.2020"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2012.9.23"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S002"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113845"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4235\/agmr.20.0078"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2174\/1389203720666191119100759"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-020-00543-y"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.04.012"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/path.4674"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00104.2021"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00048.2019"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.5.1680"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4342-z"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-5-6"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12235"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/704045"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2016.1826"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0950-x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000169"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2017.10.010"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12834"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00011.2006"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.5.1479"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950170110"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.1.168"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.6.2408"},{"key":"B40","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-201X.1942.tb11002.x","volume":"4","author":"Berggren S","year":"1942","journal-title":"Acta Physiol Scand"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00039214"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0915-6"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-019-00335-3"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105782"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1700254"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0547s70"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092283"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95911-w"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36354"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.256"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1186\/cc11439"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200710-1602OC"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.11"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00445.x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0420-x"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8076105"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00724.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T19:37:27Z","timestamp":1650915447000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00724.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,1]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,1]]}},"alternative-id":["10.1152\/japplphysiol.00724.2021"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00724.2021","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"type":"print","value":"8750-7587"},{"type":"electronic","value":"1522-1601"}],"subject":[],"published":{"date-parts":[[2022,5,1]]},"assertion":[{"value":"2021-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}