{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:08:10Z","timestamp":1788433690201,"version":"build-2803163510"},"reference-count":42,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2002,7,1]]},"abstract":"<jats:p> The relative amplitudes and rates of increase of muscle blood flow (and O<jats:sub>2<\/jats:sub> delivery) and O<jats:sub>2<\/jats:sub> uptake responses determine the O<jats:sub>2<\/jats:sub>pressure within the muscle microvasculature (Pm<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub>) across the rest-to-contraction transition. Skeletal muscle function is a primary determinant of pulmonary O<jats:sub>2<\/jats:sub> uptake kinetics; however, it has never been determined whether the dynamics of muscle Pm<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub>are faster in a highly oxidative muscle [e.g., diaphragm (Dia), citrate synthase activity of 39 \u03bcmol \u00b7 min<jats:sup>\u22121<\/jats:sup> \u00b7 g<jats:sup>\u22121<\/jats:sup>] compared with less oxidative muscles [e.g., spinotrapezius (Spino), citrate synthase activity of 14 \u03bcmol \u00b7 min<jats:sup>\u22121<\/jats:sup> \u00b7 g<jats:sup>\u22121<\/jats:sup>, male Sprague-Dawley rats; Delp MD and Duan C, J Appl Physiol80: 261\u2013270, 1996]. Phosphorescence quenching techniques (porphyrin dendrimer, R2) were used to determine Pm<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub> across the transition to electrically stimulated contractions (1 Hz) within the rat Dia. After a delay of 10.4 \u00b1 1.3 (SE) s at the beginning of Dia contractions, Pm<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub> decreased close to monoexponentially from 42 \u00b1 2 to 27 \u00b1 3 Torr ( P &lt; 0.05) with an extremely fast time constant of 7.1 \u00b1 1.1 s. Thus Dia Pm<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub> decreased with significantly ( P &lt; 0.05) faster kinetics than reported previously for the Spino muscle (delay, 19.2 \u00b1 2.8 s; time constant Pm<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub>, 21.7 \u00b1 2.1 s; Behnke BJ, Kindig CA, Musch TI, Koga S, and Poole DC, Respir Physiol126: 53\u201363, 2001). With the use of two specialized muscles with similar fiber-type composition but widely disparate oxidative capacities (Delp MD and Duan C, J Appl Physiol 80: 261\u2013270, 1996), these data demonstrate that Pm<jats:sub>O<jats:sub>2<\/jats:sub> <\/jats:sub> kinetics are significantly faster in the highly oxidative Dia compared with the low-oxidative Spino muscle and that this effect is not dependent on muscle fiber-type composition. <\/jats:p>","DOI":"10.1152\/japplphysiol.00735.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:40:57Z","timestamp":1425415257000},"page":"227-232","source":"Crossref","is-referenced-by-count":23,"title":["Dynamics of microvascular oxygen pressure  in the rat diaphragm"],"prefix":"10.1152","volume":"93","author":[{"given":"Crystal M.","family":"Geer","sequence":"first","affiliation":[{"name":"Departments of Kinesiology, Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, 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