{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:58:57Z","timestamp":1740139137933,"version":"3.37.3"},"reference-count":52,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"Eugene and Clarissa Evonuk Memorial Graduate Fellowship"},{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (CANRIMT, NSERC)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NSERC Discovery Grant and the Canadian Foundation for Innovation"},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"crossref","award":["W81XWH-10-2-0114"],"award-info":[{"award-number":["W81XWH-10-2-0114"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"name":"APS Giles F Filley Memorial Award for Excellence in Respiratory Physiology and Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:p> Subjects with a patent foramen ovale (PFO) have blunted ventilatory acclimatization to high altitude compared with subjects without PFO. The blunted response observed could be because of differences in central and\/or peripheral respiratory chemoreflexes. We hypothesized that compared with subjects without a PFO (PFO\u2212), subjects with a PFO (PFO+) would have blunted ventilatory responses to acute hypoxia and hypercapnia. Sixteen PFO+ subjects (9 female) and 15 PFO\u2212 subjects (8 female) completed four 20-min trials on the same day: 1) normoxic hypercapnia (NH), 2) hyperoxic hypercapnia (HH), 3) isocapnic hypoxia (IH), and 4) poikilocapnic hypoxia (PH). Hypercapnic trials were completed before the hypoxic trials, the order of the hypercapnic (NH &amp; HH) and hypoxic (IH &amp; PH) trials were randomized, and trials were separated by \u226540 min. During the NH trials but not the HH trials subjects who were PFO+ had a blunted hypercapnic ventilatory response compared with subjects who were PFO\u2212 (1.41\u2009\u00b1\u20090.46 l\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup> vs. 1.98\u2009\u00b1\u20090.71 l\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup>, P = 0.02). There were no differences between the PFO+ and PFO\u2212 subjects with respect to the acute hypoxic ventilatory response during IH and PH trials. Hypoxic ventilatory depression was similar between subjects who were PFO+ and PFO\u2212 during IH. These data suggest that compared with subjects who were PFO\u2212, subjects who were PFO+ have normal ventilatory chemosensitivity to acute hypoxia but blunted ventilatory chemosensitivity to carbon dioxide, possibly because of reduced carbon dioxide sensitivity of either the central and\/or the peripheral chemoreceptors. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY Patent foramen ovale (PFO) is found in ~25%\u201340% of the population. The presence of a PFO appears to be associated with blunted ventilatory responses during acute exposure to normoxic hypercapnia. The reason for this blunted ventilatory response during acute exposure to normoxic hypercapnia is unknown but may suggest differences in either central and\/or peripheral chemoreflex contribution to hypercapnia. <\/jats:p>","DOI":"10.1152\/japplphysiol.00741.2018","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T13:05:09Z","timestamp":1544101509000},"page":"730-738","source":"Crossref","is-referenced-by-count":7,"title":["Ventilatory responses to acute hypoxia and hypercapnia in humans with a patent foramen ovale"],"prefix":"10.1152","volume":"126","author":[{"given":"James T.","family":"Davis","sequence":"first","affiliation":[{"name":"Indiana State University, Department of Kinesiology, Recreation, and Sport, Terre Haute, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey M.","family":"Boulet","sequence":"additional","affiliation":[{"name":"University of British Columbia, Centre for Heart, Lung, and Vascular Health, 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