{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:27:37Z","timestamp":1775816857544,"version":"3.50.1"},"reference-count":25,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:p> To investigate the effects of colchicine on left ventricular (LV) function and hypertrophy (LVH) of rats subjected to constriction of transverse aorta (TAoC), we evaluated SO (sham operated, vehicle; n = 25), SO-T (sham operated, colchicine 0.4 mg\/kg body wt ip daily; n = 38), TAoC (vehicle; n = 37), and TAoC-T (TAoC, colchicine; n = 34) on the 2nd, 6th, and 15th day after surgery. Colchicine attenuated LVH of TAoC-T compared with TAoC rats, as evaluated by ratio between LV mass (LV<jats:sub>M<\/jats:sub>) and right ventricular mass, LV wall thickness, and average diameter of cardiac myocytes. Systolic gradient across TAoC (\u223c45 mmHg), LV systolic pressure, LV end-diastolic pressure, and rate of LV pressure increase (+dP\/d t) were comparable in TAoC-T and TAoC rats. However, the baseline and increases of LV systolic pressure-to-LV<jats:sub>M<\/jats:sub> and +dP\/d t-to-LV<jats:sub>M<\/jats:sub>ratios induced by phenylephrine infusion were greater in TAoC-T and SO-T compared with SO rats. Baseline and increases of +dP\/d t-to-LV<jats:sub>M<\/jats:sub> ratio were reduced in TAoC compared with SO rats. TAoC rats increased polymerized fraction of tubulin compared with SO, SO-T, and TAoC-T rats. Our results indicate that colchicine treatment reduced LVH to pressure overload but preserved LV function. <\/jats:p>","DOI":"10.1152\/japplphysiol.00744.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:44:35Z","timestamp":1425397475000},"page":"1627-1633","source":"Crossref","is-referenced-by-count":26,"title":["Colchicine attenuates left ventricular hypertrophy but  preserves cardiac function of aortic-constricted rats"],"prefix":"10.1152","volume":"94","author":[{"given":"Beatriz S.","family":"Scopacasa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, State University of Campinas, 13081-970 Campinas, S\u00e3o Paulo; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente P. A.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tri\u00e2ngulo Mineiro School of Medicine, 38025-440 Uberaba, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleber G.","family":"Franchini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, State University of Campinas, 13081-970 Campinas, S\u00e3o Paulo; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","first-page":"767","volume":"78","author":"Anversa P","year":"1998","journal-title":"Lab Invest"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.4.423"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0568"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/hc0102.101365"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.1.30"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01073-4"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.59.1.575"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.5.H1978"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.5.461"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.1.17"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309233291304"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102930"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5364.750"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9905"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.4.963"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.2.504"},{"key":"B17","first-page":"283","volume":"13","author":"Stromer MH.","year":"1998","journal-title":"Histol Histopathol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.82.7.751"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.6.1230"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.2.281"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.2.H341"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9224"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1126\/science.8097594"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.533"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00550-6"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00744.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:24:26Z","timestamp":1567959866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00744.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,1]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4,1]]}},"alternative-id":["10.1152\/japplphysiol.00744.2002"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00744.2002","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,1]]}}}