{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:58:23Z","timestamp":1792151903266,"version":"4.4.0"},"reference-count":35,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:p> Acetazolamide (Acz) is used at altitude to prevent acute mountain sickness, but its effect on exercise capacity under hypoxic conditions is uncertain. Nine healthy men completed this double-blind, randomized, crossover study. All subjects underwent incremental exercise to exhaustion with an inspired O<jats:sub>2<\/jats:sub> fraction of 0.13, hypoxic ventilatory responses, and hypercapnic ventilatory responses after Acz (500 mg twice daily for 5 doses) and placebo. Maximum power of 203 \u00b1 38 (SD) W on Acz was less than the placebo value of 225 \u00b1 40 W ( P &lt; 0.01). At peak exercise, arterialized capillary pH was lower and Po <jats:sub>2<\/jats:sub> higher on Acz ( P &lt; 0.01). Ventilation was 118.6 \u00b1 20.0 l\/min at the maximal power on Acz and 102.4 \u00b1 20.7 l\/min at the same power on placebo ( P &lt; 0.02), and Borg score for leg fatigue was increased on Acz ( P &lt; 0.02), with no difference in Borg score for dyspnea. Hypercapnic ventilatory response on Acz was greater ( P &lt; 0.02), whereas hypoxic ventilatory response was unchanged. During hypoxic exercise, Acz reduced exercise capacity associated with increased perception of leg fatigue. 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