{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:46:14Z","timestamp":1773261974986,"version":"3.50.1"},"reference-count":38,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p> The cardiovascular response to an arousal occurring at the termination of an obstructive apnea is almost double that to a spontaneous arousal. We investigated the hypothesis that central plus peripheral chemoreceptor stimulation, induced by hypercapnic hypoxia (HH), augments the cardiovascular response to arousal from sleep. Auditory-induced arousals during normoxia and HH (&gt;10-s duration) were analyzed in 13 healthy men [age 24 \u00b1 1 (SE) yr]. Subjects breathed on a respiratory circuit that held arterial blood gases constant, despite the increased ventilation associated with arousal. Arousals were associated with a significant increase in mean arterial blood pressure at 5 s ( P &lt; 0.001) and with a significant decrease in the R-R interval at 3 s ( P &lt; 0.001); however, the magnitude of the changes was not significantly different during normoxia compared with HH (mean arterial blood pressure: normoxia, 91 \u00b1 4 to 106 \u00b1 4 mmHg; HH, 91 \u00b1 4 to 109 \u00b1 5 mmHg; P = 0.32; R-R interval: normoxia, 1.12 \u00b1 0.04 to 1.02 \u00b1 0.05 s; HH, 1.09 \u00b1 0.05 to 0.92 \u00b1 0.04 s; P = 0.78). Mean ventilation increased significantly at the second breath postarousal for both conditions ( P &lt; 0.001), but the increase was not significantly different between the two conditions (normoxia, 5.35 \u00b1 0.40 to 9.57 \u00b1 1.69 l\/min; HH, 8.57 \u00b1 0.63 to 11.98 \u00b1 0.70 l\/min; P = 0.71). We conclude that combined central and peripheral chemoreceptor stimulation with the use of HH does not interact with the autonomic outflow associated with arousal from sleep to augment the cardiovascular response. <\/jats:p>","DOI":"10.1152\/japplphysiol.00749.2003","type":"journal-article","created":{"date-parts":[[2004,2,6]],"date-time":"2004-02-06T01:28:50Z","timestamp":1076030930000},"page":"865-870","source":"Crossref","is-referenced-by-count":23,"title":["Cardiovascular response to arousal from sleep under controlled conditions of central and peripheral chemoreceptor stimulation in humans"],"prefix":"10.1152","volume":"96","author":[{"given":"Denise M.","family":"O'Driscoll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy E.","family":"Meadows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Corfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita K.","family":"Simonds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary J.","family":"Morrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1526"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008744"},{"key":"REF3","unstructured":"Babcock MA and Badr MS. 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