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Equally important is that we are beginning to use our understanding of the cellular and molecular pathways triggered by hypoxia and hyperoxia to identify therapeutic targets to treat diseases such as cancer. We also have a better understanding of the complexities of the human respiratory responses to hypoxia; however, major deficiencies remain in our ability to alter or even measure human ventilatory responses to oxygen deficiency.<\/jats:p>","DOI":"10.1152\/japplphysiol.00755.2003","type":"journal-article","created":{"date-parts":[[2004,1,31]],"date-time":"2004-01-31T00:57:54Z","timestamp":1075510674000},"page":"352-358","source":"Crossref","is-referenced-by-count":12,"title":["Oxygen sensing: applications in humans"],"prefix":"10.1152","volume":"96","author":[{"given":"Neil S","family":"Cherniack","sequence":"first","affiliation":[{"name":"New Jersey Medical School, The University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07301"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","unstructured":"Agani F, Kirsch DG, Friedman SL, Kastan MB, and Semenza GL.p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.Cancer Res57: 4474-4477, 1997."},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108665"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.2.685"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(86)90075-7"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.4.309"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80289-4"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200301000-00010"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00112-1"},{"key":"REF9","unstructured":"Cherniack NS, Dempsey J, Fencl V, Fitzgerald RS, Lourenco RV, Rebuck AS, Rigg J, Severinghaus JW, Weil JW, Whitelaw WA, and Zwilich CW.Workshop on assessment of respiratory control in humans. 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