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Plasma AVP levels (means \u00b1 SD) were significantly elevated at 24 h (42 \u00b1 21 pg\/ml), 48 h (50 \u00b1 28 pg\/ml), and 72 h (110 \u00b1 47 pg\/ml), and returned to baseline at 96 h (22 \u00b1 15 pg\/ml) following middle cerebral artery occlusion compared with sham-operated controls (14 \u00b1 7 pg\/ml). Plasma AVP levels at 72 h were significantly attenuated with 7.5% HS (37 \u00b1 8 pg\/ml; 360 \u00b1 11 osmol\/l) compared with 0.9% saline (73 \u00b1 6; 292 \u00b1 6 osmol\/l), 3% HS (66 \u00b1 8 pg\/ml; 303 \u00b1 12 osmol\/l), or mannitol (74 \u00b1 9 pg\/ml; 313 \u00b1 14 osmol\/l) treatment. HS (7.5%) significantly attenuated water content in the ipsilateral and contralateral hemispheres compared with surgical shams, 0.9% saline, 3% HS, and mannitol treatments. Peak plasma AVP levels were not associated with direct histopathological injury to the anterior hypothalamus. Attenuation of brain water content with 7.5% HS treatment coincides with attenuated serum AVP levels, and we speculate that this may represent one additional mechanism by which osmotherapy attenuates edema associated with ischemic stroke.<\/jats:p>","DOI":"10.1152\/japplphysiol.00763.2005","type":"journal-article","created":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T01:44:22Z","timestamp":1134092662000},"page":"1445-1451","source":"Crossref","is-referenced-by-count":33,"title":["Plasma arginine-vasopressin following experimental stroke: effect of osmotherapy"],"prefix":"10.1152","volume":"100","author":[{"given":"Yi","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Hung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J.","family":"Crain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J. 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