{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:37:13Z","timestamp":1775245033710,"version":"3.50.1"},"reference-count":40,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:p>Environmentally relevant doses of inhaled diesel particles elicit pulmonary inflammation and impair lung mechanics. Eugenol, a methoxyphenol component of clove oil, presents in vitro and in vivo anti-inflammatory and antioxidant properties. Our aim was to examine a possible protective role of eugenol against lung injuries induced by diesel particles. Male BALB\/c mice were divided into four groups. Mice received saline (10 \u03bcl in; CTRL group) or 15 \u03bcg of diesel particles DEP (15 \u03bcg in; DIE and DEUG groups). After 1 h, mice received saline (10 \u03bcl; CTRL and DIE groups) or eugenol (164 mg\/kg; EUG and DEUG group) by gavage. Twenty-four hours after gavage, pulmonary resistive (\u0394P1), viscoelastic (\u0394P2) and total (\u0394Ptot) pressures, static elastance (Est), and viscoelastic component of elastance (\u0394E) were measured. We also determined the fraction areas of normal and collapsed alveoli, amounts of polymorpho- (PMN) and mononuclear cells in lung parenchyma, apoptosis, and oxidative stress. Est, \u0394P2, \u0394Ptot, and \u0394E were significantly higher in the DIE than in the other groups. DIE also showed significantly more PMN, airspace collapse, and apoptosis than the other groups. However, no beneficial effect on lipid peroxidation was observed in DEUG group. In conclusion, eugenol avoided changes in lung mechanics, pulmonary inflammation, and alveolar collapse elicited by diesel particles. It attenuated the activation signal of caspase-3 by DEP, but apoptosis evaluated by TUNEL was avoided. Finally, it could not avoid oxidative stress as indicated by malondialdehyde.<\/jats:p>","DOI":"10.1152\/japplphysiol.00764.2011","type":"journal-article","created":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T05:09:53Z","timestamp":1324616993000},"page":"911-917","source":"Crossref","is-referenced-by-count":36,"title":["Eugenol attenuates pulmonary damage induced by diesel exhaust particles"],"prefix":"10.1152","volume":"112","author":[{"given":"Walter A.","family":"Zin","sequence":"first","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana G. L. 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