{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:28:52Z","timestamp":1790483332771,"version":"4.1.0"},"reference-count":34,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p> The physical and physiological behavior of sickle cell trait carriers (AS) is somewhat equivocal under strenuous conditions, although this genetic abnormality is generally considered to be a benign disorder. The occurrence of incidents and severe injuries in AS during exercise might be explained, in part, by the lactic acidosis due to a greater lactate influx into AS red blood cells (RBCs). In the present study, the RBC lactate transport activity via the different pathways was compared between AS and individuals with normal hemoglobin (AA). Sixteen Caribbean students, nine AS and seven AA, performed a progressive and maximal exercise test to determine maximal oxygen consumption. Blood samples were obtained at rest to assess haematological parameters and RBC lactate transport activity. Lactate influxes [total lactate influx and monocarboxylate transporter (MCT-1)-mediated lactate influx] into erythrocytes were measured at four external [<jats:sup>14<\/jats:sup>C]-labeled lactate concentrations (1.6, 8.1, 41, and 81.1 mM). The two groups had similar maximal oxygen consumption. Total lactate influx and lactate influx via the MCT-1 pathway were significantly higher in AS compared with AA at 1.6, 41, and 81.1 mM. The maximal lactate transport capacity for MCT-1 was higher in AS than in AA. Although AS and AA had the same maximal aerobic physical fitness, the RBCs from the sickle cell trait carriers took up more lactate at low and high concentrations than the RBCs from AA individuals. The higher MCT-1 maximal lactate transport capacity found in AS suggests greater content or greater activity of MCT-1 in AS RBC membranes. <\/jats:p>","DOI":"10.1152\/japplphysiol.00771.2005","type":"journal-article","created":{"date-parts":[[2005,10,26]],"date-time":"2005-10-26T03:43:25Z","timestamp":1130298205000},"page":"427-432","source":"Crossref","is-referenced-by-count":10,"title":["Faster lactate transport across red blood cell membrane in sickle cell trait carriers"],"prefix":"10.1152","volume":"100","author":[{"given":"Sara","family":"Fagn\u00e9t\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connes","family":"Philippe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hue","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montout-Hedreville","family":"Mona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne-Julan","family":"Maryse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardy-Dessources","family":"Marie-Dominique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199805000-00002"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17611"},{"key":"R3","unstructured":"Bitanga E and Rouillon JD. Influence of the sickle cell trait heterozygote on energy abilities. Pathol Biol (Paris) 46: 46\u201352, 1998."},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198606000-00019"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200004000-00011"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00993.2003"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00715.2003"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Davis AM. Sickle-cell trait as a risk factor for sudden death in physical training. N Engl J Med 318: 787, 1988.","DOI":"10.1056\/NEJM198803243181215"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(82)90053-0"},{"key":"R10","unstructured":"Diara JP, Bibrac A, Saint-Martin C, Keclard L, and Etienne-Julan M. Interest of the early undertake of sickle cell disease: experiment of Guadeloupe. In: La Dr\u00e9panocytose, edited by Girot R, B\u00e9gu\u00e9 P, and Galact\u00e9ros F. Montrouge, France: John Libbey Eurotext, 2003, p. 303\u2013315."},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.1.49"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-973032"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199212000-00004"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03330300061037"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199503000-00013"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-23175"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.035899"},{"key":"R18","unstructured":"Le Gallais D, Bile A, Mercier J, Paschel M, Tonellot JL, and Dauverchain J. Exercise-induced death in sickle cell trait: role of aging, training, and deconditioning. Med Sci Sports Exerc 28: 541\u2013544, 1996."},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1089\/15270290260131911"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000170128.78432.96"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00235.2005"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.264.4.C761"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1080\/026404199365795"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1097\/00042752-200303000-00006"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107199"},{"key":"R26","unstructured":"Sears DA. Sickle cell trait. In: Sickle Cell Disease: Basic Principles and Clinical Practice, edited by Embury SH, Hebbel RP, Mohandas N, and Steinberg MH. New York: Raven, 1994, p. 381\u2013394."},{"key":"R27","unstructured":"Sergeant GR and Sergeant BE. Distribution of sickle cell disease. In: Sickle Cell Disease: Oxford Univ. Press, 2001, p. 16\u201330."},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1995.268.5.R1121"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199804000-00011"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050126"},{"key":"R31","doi-asserted-by":"crossref","unstructured":"Thiriet P, Lobe MM, Gweha I, and Gozal D. Prevalence of the sickle cell trait in an athletic West African population. Med Sci Sports Exerc 23: 389\u2013390, 1991.","DOI":"10.1249\/00005768-199103000-00020"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.1.R19"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.4.R1025"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198606000-00017"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00771.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:30:09Z","timestamp":1567963809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00771.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1152\/japplphysiol.00771.2005"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00771.2005","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}