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In support of our hypothesis, both conventional flow-mediated dilation (FMD) testing and brachial artery vasodilation in response to sustained elevations in shear rate during handgrip exercise increased significantly in patients with HFpEF following statin administration, beneficial effects that were accompanied by a decrease in biomarkers of oxidative damage. However, contrary to our hypothesis, reactive hyperemia and exercise hyperemia were unchanged in patients with HFpEF following statin therapy. These data provide new evidence for the efficacy of low-dose statin administration to improve brachial artery endothelium-dependent vasodilation, but not microvascular reactivity or exercising muscle blood flow in patients with HFpEF, which may be due in part to reductions in oxidative stress. <\/jats:p>","DOI":"10.1152\/japplphysiol.00775.2023","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T09:04:09Z","timestamp":1708592649000},"page":"877-888","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Statin administration improves vascular function in heart failure with preserved ejection fraction"],"prefix":"10.1152","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2335-453X","authenticated-orcid":false,"given":"Jarred J.","family":"Iacovelli","sequence":"first","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9769-4966","authenticated-orcid":false,"given":"Jeremy K.","family":"Alpenglow","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6300-7600","authenticated-orcid":false,"given":"Stephen M.","family":"Ratchford","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5959-4139","authenticated-orcid":false,"given":"Jesse C.","family":"Craig","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah M.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States"},{"name":"Department of Chemistry, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van","family":"Reese","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-6634","authenticated-orcid":false,"given":"Kanokwan","family":"Bunsawat","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States"},{"name":"Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy L.","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6907-1734","authenticated-orcid":false,"given":"D. 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