{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:13:16Z","timestamp":1787616796917,"version":"build-2736575974"},"reference-count":44,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["05293"],"award-info":[{"award-number":["05293"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005156","name":"Brock University","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["00320"],"award-info":[{"award-number":["00320"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["00094"],"award-info":[{"award-number":["00094"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ontario Graduate Scholarship Program","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Queen Elizabeth II Graduate Scholarship in Science and Technology","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>Our knowledge regarding human baroreflex regulation of sympathetic action potential (AP) discharge remains incomplete. Cardiac arrhythmias in a healthy female provided a unique opportunity to examine baroreflex regulation of sympathetic AP discharge during large, rapid blood pressure changes. Our novel findings include: 1) rapid baroreflex loading due to ventricular bigeminy reduced AP discharge and derecruited large APs, 2) as bigeminy continued, rapid baroreflex resetting increased AP discharge, and 3) rapid baroreflex loading reduced AP latency.<\/jats:p>","DOI":"10.1152\/japplphysiol.00781.2025","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T11:52:12Z","timestamp":1764762732000},"page":"208-219","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Baroreflex regulation of sympathetic neuronal discharge during large, rapid changes in blood pressure caused by ventricular bigeminy and sinus pause"],"prefix":"10.1152","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6188-4829","authenticated-orcid":false,"given":"Nathaniel J.","family":"Iannarelli","sequence":"first","affiliation":[{"name":"Brock University","place":["Canada"]},{"name":"Brock Functional Inclusive Training Centre (Bfit)","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3420-3993","authenticated-orcid":false,"given":"Cameron M.","family":"Lynn","sequence":"additional","affiliation":[{"name":"Brock University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2110-5079","authenticated-orcid":false,"given":"Julia E.","family":"Spafford","sequence":"additional","affiliation":[{"name":"Brock Functional Inclusive Training Centre (Bfit)","place":["Canada"]},{"name":"Brock University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Sattin","sequence":"additional","affiliation":[{"name":"University of Western Ontario","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-1536","authenticated-orcid":false,"given":"Deborah D.","family":"O\u2019Leary","sequence":"additional","affiliation":[{"name":"Brock University","place":["Canada"]},{"name":"Brock Functional Inclusive Training Centre (Bfit)","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-4978","authenticated-orcid":false,"given":"Stephen S.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Brock University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4560-8728","authenticated-orcid":false,"given":"Stephen A.","family":"Klassen","sequence":"additional","affiliation":[{"name":"Brock Functional Inclusive Training Centre (Bfit)","place":["Canada"]},{"name":"Brock University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-201X.1968.tb10904.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1972.tb05157.x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00030-6"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/JP279326"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00925.2011"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(92)90200-Z"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0861h.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020025"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(80)90098-2"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00841.2017"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(93)90125-E"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.195941"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00935.2017"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1987.253.6.R929"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00395.2021"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00375.2013"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1982.242.2.H185"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013604"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00814.2010"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00640.2017"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00077.2015"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00703.2016"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2011.12.003"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3109\/00365517409049883"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0901-8"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.8.1870"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(68)90156-8"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.08.035"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2020.102743"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2307\/2335182"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00258.2019"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00347.2022"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030010110"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1934.110.3.708"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.6.H2000"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1989.tb02994.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015203"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1980.239.1.R42"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1980.239.1.R48"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.6.H2563"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c220027"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00045.2022"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(83)80014-X"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.72.2.440"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00781.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T22:17:41Z","timestamp":1773353861000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00781.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["10.1152\/japplphysiol.00781.2025"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00781.2025","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"assertion":[{"value":"2025-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}