{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:42:58Z","timestamp":1789540978798,"version":"build-2803163510"},"reference-count":72,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000104","name":"NASA Nebraska Space Grant Fellowship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Sherwood Foundation","award":["5444"],"award-info":[{"award-number":["5444"]}]},{"DOI":"10.13039\/100009499","name":"University of Nebraska at Omaha Graduate Research and Creative Activity Grant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009499","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000104","name":"NASA Nebraska Space Grant","doi-asserted-by":"publisher","award":["NNX15AI09H"],"award-info":[{"award-number":["NNX15AI09H"]}],"id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000104","name":"NASA Nebraska Space Grant","doi-asserted-by":"publisher","award":["80NSSC20M0112"],"award-info":[{"award-number":["80NSSC20M0112"]}],"id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM109090"],"award-info":[{"award-number":["P20GM109090"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R00HL125756"],"award-info":[{"award-number":["R00HL125756"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p> Passive leg movement could not preserve macrovascular endothelial function, whereas active leg movement could protect endothelial function. Attenuated microvascular function can be salvaged by passive movement and active movement. Preservation of macrovascular hemodynamics and plasma total nitrate\/nitrite and endothelin-1 during prolonged sitting requires active movement. These findings dissociate the impacts induced by mechanical stress (passive movement) from the change in metabolism (active movement) on the vasculature during prolonged sitting in a mild hypercapnic environment. <\/jats:p>","DOI":"10.1152\/japplphysiol.00799.2021","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T13:32:46Z","timestamp":1645104766000},"page":"874-887","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of passive and active leg movements to interrupt sitting in mild hypercapnia on cardiovascular function in healthy adults"],"prefix":"10.1152","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8576-7531","authenticated-orcid":true,"given":"Song-Young","family":"Park","sequence":"first","affiliation":[{"name":"School of Health and Kinesiology, University of Nebraska Omaha, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TeSean K.","family":"Wooden","sequence":"additional","affiliation":[{"name":"School of Health and Kinesiology, University of Nebraska Omaha, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Pekas","sequence":"additional","affiliation":[{"name":"School of Health and Kinesiology, University of Nebraska Omaha, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody P.","family":"Anderson","sequence":"additional","affiliation":[{"name":"School of Health and Kinesiology, University of Nebraska Omaha, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-4561","authenticated-orcid":true,"given":"Santosh K.","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7337-3770","authenticated-orcid":true,"given":"Dustin R.","family":"Slivka","sequence":"additional","affiliation":[{"name":"School of Health and Kinesiology, University of Nebraska Omaha, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5029-2457","authenticated-orcid":true,"given":"Gwenael","family":"Layec","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Massachusetts Amherst, Amherst, Massachusetts"},{"name":"Institute for Applied Life Sciences, Amherst, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0882"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181930355"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.031"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031132"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3307-3"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000479"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13478"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00544.2018"},{"key":"B9","first-page":"226","volume":"53","author":"Shvartz E","year":"1982","journal-title":"Aviat Space Envir Md"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.6.1673"},{"key":"B11","first-page":"79","volume":"114","author":"Ross R","year":"1984","journal-title":"Am J Pathol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/000331979905000805"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.10.011"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2014.01.04"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2015.04.002"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/ina.12392"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00354.2020"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00297.2016"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00482.2010"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00038.2011"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00979.2013"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1310\/sci18-00020"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1113\/EP085238"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00851.2011"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00318.2019"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-1838(97)00067-2"},{"key":"B28","doi-asserted-by":"crossref","first-page":"63p","DOI":"10.1113\/jphysiol.1969.sp008898","volume":"204","author":"Jones PR","year":"1969","journal-title":"J Physiol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.6.2375"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01120.2013"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00744.2019"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.5.564"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00258"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.150821"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520002548"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000777"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1113\/EP087444"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00319.2012"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00925.2011"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00920.2005"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2013.10.004"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3233\/CH-141816"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-020-01325-5"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00943.2015"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1998.0324e.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12725"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00286.2016"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-12-50"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1113\/EP086918"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00823.2016"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.10.014"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.2018-0568"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00038.2011"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00557.2017"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.224741"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244841"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00422.2020"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1113\/EP088690"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00761.x"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.18.5.677"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00397.2010"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00057"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2005.04.008"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.4.829"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.4.931"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238411"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.209353"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00462.2010"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00806.2016"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00533.2017"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2021.104147"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15754"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz350"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00799.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T20:40:04Z","timestamp":1647376804000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00799.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,1]]}},"alternative-id":["10.1152\/japplphysiol.00799.2021"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00799.2021","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]},"assertion":[{"value":"2021-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}