{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:04:08Z","timestamp":1778789048848,"version":"3.51.4"},"reference-count":60,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100015752","name":"BC Lung Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015752","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001448","name":"Alpha-1 Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001448","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:p> Stereology has been the gold standard to quantify the three-dimensional lung anatomy using two-dimensional microscopy images. However, such techniques are labor intensive. This study provides a method that applies stereology to volumetric computed tomography images of frozen whole human lungs and systematic uniform random samples. The method yielded a comprehensive data set on the small airways and parenchymal lung structures, highlighting morphometric sex differences and providing a reference data set for future pathological studies. <\/jats:p>","DOI":"10.1152\/japplphysiol.00803.2019","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T16:21:16Z","timestamp":1587054076000},"page":"1604-1616","source":"Crossref","is-referenced-by-count":47,"title":["Comprehensive stereological assessment of the human lung using multiresolution computed tomography"],"prefix":"10.1152","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-4365","authenticated-orcid":false,"given":"Drago\u015f M.","family":"Vasilescu","sequence":"first","affiliation":[{"name":"Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 B.","family":"Phillion","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kinose","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn E.","family":"Verleden","sequence":"additional","affiliation":[{"name":"Leuven Lung Transplant Unit, Katholieke Universiteit Leuven and Universitair Ziekenhuis Leuven-Gasthuisberg, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart M.","family":"Vanaudenaerde","sequence":"additional","affiliation":[{"name":"Leuven Lung Transplant Unit, Katholieke Universiteit Leuven and Universitair Ziekenhuis Leuven-Gasthuisberg, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert M.","family":"Verleden","sequence":"additional","affiliation":[{"name":"Leuven Lung Transplant Unit, Katholieke Universiteit Leuven and Universitair Ziekenhuis Leuven-Gasthuisberg, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Van Raemdonck","sequence":"additional","affiliation":[{"name":"Leuven Lung Transplant Unit, Katholieke Universiteit Leuven and Universitair Ziekenhuis Leuven-Gasthuisberg, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher S.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Lung Cancer Initiative, Johnson and Johnson, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron J.","family":"Hague","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MeiLan K.","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel D.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tillie-Louise","family":"Hackett","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Hogg","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0676"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.5.1525"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201506-371PP"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00440.2018"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.17.4.329"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(78)90104-4"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00167908"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2818.1999.00457.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092200410"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00094.2014"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(86)90092-7"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201310-364OC"},{"key":"B13","series-title":"Lung Biology in Health and Disease","volume-title":"Complexity in Structure and Function of the Lung","volume":"121","author":"Hoffman EA","year":"1998"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.5.1414"},{"key":"B14a","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1968.24.3.373"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200809-1522ST"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1080\/01926230601059977"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20012"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1029\/92JB02298"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2011.586658"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01100.2009"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20747"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30196-6"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S52637"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/thx.34.4.527"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21161"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015141579"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200606-828OC"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01017.2014"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106955"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-056-4_18"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00427.2012"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.4.782"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200308-1107OC"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.1986.1.2.178"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-059OC"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7061(92)90062-C"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1378\/chest.56.2.126"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001800204"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166745"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01245-2017"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201602-0278OC"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1967.95.5.765"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2010.03481.x"},{"key":"B44","volume-title":"Clinical Hematology: Theory and Procedures","author":"Turgeon ML","year":"2005"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215112109"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00855.2012"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00838.2016"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201310-1894OC"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02117.x"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2363041142"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-87553-3"},{"key":"B52","volume-title":"Stereological Methods: Practical Methods for Biological Morphometry","author":"Weibel ER","year":"1979"},{"key":"B53","volume-title":"Respiratory Physiology: People and Ideas","author":"Weibel ER","year":"2013"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1126\/science.137.3530.577"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.2118\/16983-PA"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070320308"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1998.tb01395.x"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.5.1687"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e318262292e"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00803.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T17:35:44Z","timestamp":1591637744000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00803.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6,1]]}},"alternative-id":["10.1152\/japplphysiol.00803.2019"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00803.2019","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]}}}