{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:56:24Z","timestamp":1774414584736,"version":"3.50.1"},"reference-count":47,"publisher":"American Physiological Society","issue":"1","funder":[{"name":"Cherry Research Committee"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:p> Flavonoid supplementation improves brachial artery flow-mediated dilation (FMD), but it is not known whether flavonoids protect against vascular dysfunction induced by ischemia-reperfusion (IR) injury and associated respiratory burst. In a randomized, double-blind, placebo-controlled, crossover study, we investigated whether 4 wk supplementation with freeze-dried Montmorency cherry (MC) attenuated suppression of FMD after IR induced by prolonged forearm occlusion. Twelve physically inactive overweight, middle-aged men (52.8\u2009\u00b1\u20095.8 yr, BMI: 28.1\u2009\u00b1\u20095.3 kg\/m<jats:sup>2<\/jats:sup>) consumed MC (235 mg\/day anthocyanins) or placebo capsules for 4 wk, with supplementation blocks separated by 4 wk washout. Before and after each supplementation block, FMD responses and plasma nitrate and nitrite ([[Formula: see text]]) concentrations were measured at baseline and 15, 30, and 45 min after prolonged (20 min) forearm occlusion. FMD response was significantly depressed by the prolonged occlusion ( P &lt; 0.001). After a 45-min reperfusion, FMD was restored to baseline levels after MC (\u0394FMD presupplementation: \u221230.5\u2009\u00b1\u20098.4%, postsupplementation: \u22120.6\u2009\u00b1\u20099.5%) but not placebo supplementation (\u0394FMD presupplementation: \u221211.6\u2009\u00b1\u200910.6, postsupplementation: \u221225.4\u2009\u00b1\u20094.0%; condition \u00d7 supplement interaction: P = 0.038). Plasma [[Formula: see text]] decreased after prolonged occlusion but recovered faster after MC compared with placebo (\u039445 min to baseline; MC: presupplementation: \u221215.3\u2009\u00b1\u20099.6, postsupplementation: \u22126.2\u2009\u00b1\u20098.1; Placebo: presupplementation: \u221216.3\u2009\u00b1\u20095.9, postsupplementation: \u221227.7\u2009\u00b1\u200911.1 nmol\/l; condition \u00d7 supplement \u00d7 time interaction: P = 0.033). Plasma peroxiredoxin concentration ([Prx2]) was significantly higher after MC (presupplementation: 22.8\u2009\u00b1\u20091.4, postsupplementation: 28.0\u2009\u00b1\u20092.4 ng\/ml, P = 0.029) but not after placebo supplementation (presupplementation: 22.1\u2009\u00b1\u20092.2, postsupplementation: 23.7\u2009\u00b1\u20091.5 ng\/ml). In conclusion, 4 wk MC supplementation enhanced recovery of endothelium-dependent vasodilatation after IR, in parallel with faster recovery of plasma [[Formula: see text]], suggesting NO dependency. These protective effects seem to be related to increased plasma [Prx2], presumably conferring protection against the respiratory burst during reperfusion. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY This is the first study to demonstrate that 4 wk of Montmorency cherry powder supplementation exerted protective effects on endothelium-dependent vasodilation after transient ischemia-reperfusion injury in overweight, physically inactive, nonmedicated, hypertensive middle-aged men. These effects seem to be due to increased nitric oxide availability, as evidenced by higher plasma nitrite concentration and peak arterial diameter during the flow-mediated dilation measurement. This may be a consequence of increased concentration of peroxiredoxin and other antioxidant systems and, hence, reduced reactive oxygen species exposure. <\/jats:p>","DOI":"10.1152\/japplphysiol.00804.2018","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T18:05:18Z","timestamp":1543514718000},"page":"246-254","source":"Crossref","is-referenced-by-count":21,"title":["Montmorency cherry supplementation attenuates vascular dysfunction induced by prolonged forearm occlusion in overweight, middle-aged men"],"prefix":"10.1152","volume":"126","author":[{"given":"Zainie","family":"Aboo Bakkar","sequence":"first","affiliation":[{"name":"Sport and Health Sciences, University of Exeter, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Fulford","sequence":"additional","affiliation":[{"name":"University of Exeter Medical School, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip E.","family":"Gates","sequence":"additional","affiliation":[{"name":"University of Exeter Medical School, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-8266","authenticated-orcid":false,"given":"Sarah R.","family":"Jackman","sequence":"additional","affiliation":[{"name":"Sport and Health Sciences, University of Exeter, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Sport and Health Sciences, University of Exeter, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Bond","sequence":"additional","affiliation":[{"name":"Sport and Health Sciences, University of Exeter, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna L.","family":"Bowtell","sequence":"additional","affiliation":[{"name":"Sport and Health Sciences, University of Exeter, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.03.008"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007975"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405547200"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.317S"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01243.2005"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.162743"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002290"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00360.2015"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00074.2015"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31820e5adc"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200506000-00028"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000033"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.10.2588"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00845.2010"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.004242"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.02.044"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldh025"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00094-X"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.1.38"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.10.002"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-0988-9"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.123869"},{"key":"B23","first-page":"245","volume":"16","author":"Kelishadi R","year":"2011","journal-title":"J Res Med Sci"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.04.006"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.12.1624"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200504"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.002"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.12.001"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.03.007"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.5.H2327"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.814731"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4623"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2466"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00515.2003"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.06.011"},{"key":"B36","first-page":"305","volume":"16","author":"Poreba R","year":"2009","journal-title":"Ann Agric Environ Med"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055385"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.066639"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2012-0450"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00356-4"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00471.2010"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.111716"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4490"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451300278X"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00372.2013"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-013-2589-8"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000135868.38343.c6"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00804.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T12:03:14Z","timestamp":1567944194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00804.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,1]]}},"alternative-id":["10.1152\/japplphysiol.00804.2018"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00804.2018","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]}}}