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Nine piglets were subjected to 30 min of HI by occluding both carotid arteries and reducing the fraction of inspired oxygen to 8%. An additional nine piglets served as sham-operated controls. Measurements of CBF, oxygen extraction fraction (OEF), and CMRO<jats:sub>2<\/jats:sub> were obtained at baseline and at 6 h after the HI insult. Of the three parameters, only CMRO<jats:sub>2<\/jats:sub> showed a persistent and significant change after HI. Five minutes after reoxygenation, there was a 28 \u00b1 12% (mean \u00b1 SE) decrease in CMRO<jats:sub>2<\/jats:sub>, a 72 \u00b1 50% increase in CBF, and a 56 \u00b1 19% decrease in OEF compared with baseline ( P &lt; 0.05). By 30 min postinsult and for the remainder of the study, there were no significant differences in CBF and OEF between control and insult groups, whereas CMRO<jats:sub>2<\/jats:sub> remained depressed throughout the 6-h postinsult period. This study demonstrates that NIRS can measure decreases in CMRO<jats:sub>2<\/jats:sub> caused by HI. The results highlight the potential for NIRS to be used in the neonatal intensive care unit to detect delayed brain damage. <\/jats:p>","DOI":"10.1152\/japplphysiol.00830.2005","type":"journal-article","created":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T01:33:54Z","timestamp":1132277634000},"page":"850-857","source":"Crossref","is-referenced-by-count":44,"title":["Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets"],"prefix":"10.1152","volume":"100","author":[{"given":"Kenneth M.","family":"Tichauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek W.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hadway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yim","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith St.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1053\/ejpn.2000.0307"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Blumberg RM, Cady EB, Wigglesworth JS, McKenzie JE, and Edwards AD. 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