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A fast Fourier transform spectral analysis of the breath-by-breath ventilation (V\u0307e) signal, O<jats:sub>2<\/jats:sub>saturation, and end-tidal PCO<jats:sub>2<\/jats:sub>evidenced a periodic pattern with a period of 11.1 to 12.0 s. The peak power of the V\u0307e spectrum was higher in the high HVRe group ( P &lt; 0.001). A prospective study (25 subjects) was performed to evaluate the influence of cardiorespiratory factors on the amplitude and period of oscillations in various conditions of exercise (20 to 40% maximal aerobic power) and hypoxia (0 to 4,000 m altitude). The period of V\u0307e was shorter at exercise (vs. rest, P &lt; 0.001) and hypoxia (vs. normoxia, P &lt; 0.001), and inversely related with cardiac output and V\u0307e ( P &lt; 0.001). V\u0307e peak power was higher at exercise ( P &lt; 0.001) and hypoxia ( P &lt; 0.001), and was positively related with cardiac output and V\u0307e ( P &lt; 0.001). V\u0307e peak power in hypoxia was positively related with the ventilatory response to CO<jats:sub>2<\/jats:sub>(HCVR). This novel observation suggests that healthy subjects demonstrate a spontaneous periodic breathing, not clearly observable at rest and in normoxia, but triggered by hypoxic exercise. The periodic pattern is enhanced in subjects with high HVRe and high HCVR, suggesting that oxygen and CO<jats:sub>2<\/jats:sub>play synergistic roles in the modulation of these oscillations.<\/jats:p>","DOI":"10.1152\/japplphysiol.00832.2014","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T05:23:14Z","timestamp":1415942594000},"page":"115-123","source":"Crossref","is-referenced-by-count":26,"title":["Periodic breathing in healthy humans at exercise in hypoxia*"],"prefix":"10.1152","volume":"118","author":[{"given":"Eric","family":"Hermand","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris 13, Sorbonne Paris Cit\u00e9, Laboratoire Hypoxie et poumon, Bobigny, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Pichon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 13, Sorbonne Paris Cit\u00e9, Laboratoire Hypoxie et poumon, Bobigny, France; 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