{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:03:14Z","timestamp":1790643794500,"version":"4.1.0"},"reference-count":53,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100020013","name":"NIHR | NIHR Leicester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p> Data from supine, sitting, and standing postures were measured. Modeling the data with logistic curves to express the effects of CO<jats:sub>2<\/jats:sub> reactivity on middle cerebral artery blood velocity (MCAv), posterior cerebral artery blood velocity (PCAv), heart rate, blood pressure (BP), and the autoregulation index (ARI), provided a more comprehensive approach to study the interaction of arterial CO<jats:sub>2<\/jats:sub> with posture than in previous studies. Above all, shifts of the logistic curve model with changes in posture have shown interactions with [Formula: see text] that have not been previously demonstrated. <\/jats:p>","DOI":"10.1152\/japplphysiol.00851.2023","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T08:01:17Z","timestamp":1723708877000},"page":"892-902","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The complexity of cerebral blood flow regulation: the interaction of posture and vasomotor reactivity"],"prefix":"10.1152","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-8055","authenticated-orcid":false,"given":"Rebecca H.","family":"Clough","sequence":"first","affiliation":[{"name":"Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6983-8707","authenticated-orcid":false,"given":"Ronney B.","family":"Panerai","sequence":"additional","affiliation":[{"name":"Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom"},{"name":"NIHR Leicester Biomedical Research Centre, British Heart Foundation Cardiovascular Research Centre, Glenfield Hospital, Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3588-3619","authenticated-orcid":false,"given":"Kannaphob","family":"Ladthavorlaphatt","sequence":"additional","affiliation":[{"name":"Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom"},{"name":"Medical Diagnostics Unit, Thammasat University Hospital, Thammasat University, Pathumthani, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-2468","authenticated-orcid":false,"given":"Thompson G.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom"},{"name":"NIHR Leicester Biomedical Research Centre, British Heart Foundation Cardiovascular Research Centre, Glenfield Hospital, Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-9105","authenticated-orcid":false,"given":"Jatinder S.","family":"Minhas","sequence":"additional","affiliation":[{"name":"Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom"},{"name":"NIHR Leicester Biomedical Research Centre, British Heart Foundation Cardiovascular Research Centre, Glenfield Hospital, Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2020"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15617954"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c180021"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s10558-007-9044-6"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.594168"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.27.10.1829"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211065204"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.20.1.45"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211029049"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.268953"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00100.2022"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229049"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/aafab6"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01157.2009"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221119760"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/aac76b"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/24\/2\/312"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2013.09.004"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.91008.2008"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.228551"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.54"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01186.2002"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.07.048"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3357\/asem.3269.2012"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000120729.99039.B6"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1159\/000047741"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-807OC"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.137075"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.230425"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00906.2006"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.206052"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00963.2020"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.11.1484"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.3.H1040"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.056895"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00446.2005"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00086.2014"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13150"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120335"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1113\/JP273557"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.3.R716"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0338-1"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.permed.2012.02.052"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-30332-7_16"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.04.038"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.08.015"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/BF03325235"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6623093"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2014"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00651.2014"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.129395"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.3.1084"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1042\/CS20080236"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00851.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:40:38Z","timestamp":1727455238000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00851.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10,1]]}},"alternative-id":["10.1152\/japplphysiol.00851.2023"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00851.2023","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"assertion":[{"value":"2023-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}