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Following acute hemodilution, nephrectomy prevented the adaptive increase in CO associated with acute hemodilution leading to a further reduction in P<jats:sub>Br<\/jats:sub>o<jats:sub>2<\/jats:sub>, accentuating the degree of cerebral tissue hypoxia. These data support a role for the kidney in maintaining P<jats:sub>Br<\/jats:sub>o<jats:sub>2<\/jats:sub> and initiating the increase in CO that optimized brain perfusion during acute anemia. <\/jats:p>","DOI":"10.1152\/japplphysiol.00858.2023","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T09:04:09Z","timestamp":1708592649000},"page":"1245-1259","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral nephrectomy impairs cardiovascular function and cerebral perfusion in a rat model of acute hemodilutional anemia"],"prefix":"10.1152","volume":"136","author":[{"given":"Kyle","family":"Chin","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, St Michael\u2019s Hospital, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Physiology, University of Toronto, Toronto, Ontario, 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