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A prospective study (three yearly measurements) included 81 healthy male subjects: 16 sedentary lean subjects, and 3 groups of runners (5\u201330 km\/wk, n = 19; 30\u201350 km\/wk, n = 29; 50\u2013100 km\/wk, n = 17). Several measurements were performed at the proximal tibia level: volumetric BMD (vBMD) and cortical index (CI), i.e., an index of cortical bone thickness and peak accelerations (an index of shocks during heel strike) while running (measured by a three-dimensional accelerometer). A general linear model assessed the prediction of vBMD or CI by 1) simple effects (running distance, peak accelerations, time); and 2) interactions (for instance, if vBMD prediction by peak acceleration depends on running distance). CI and vBMD 1) increase with running distance to reach a plateau over 30 km\/wk; and 2) are positively associated with peak accelerations over 30 km\/wk. Running may be associated with high peak accelerations to have beneficial effects on BMD. More important strains are needed to be associated with the same increase in BMD during running sessions of short duration than those of long duration. CI and vBMD are associated with the magnitude of the shocks during heel strike in runners.<\/jats:p>","DOI":"10.1152\/japplphysiol.00865.2009","type":"journal-article","created":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T02:51:04Z","timestamp":1265338264000},"page":"852-857","source":"Crossref","is-referenced-by-count":7,"title":["Proximal tibia volumetric bone mineral density is correlated to the magnitude of local acceleration in male long-distance runners"],"prefix":"10.1152","volume":"108","author":[{"given":"Olivier","family":"D\u00e9riaz","sequence":"first","affiliation":[{"name":"Institut de Recherche en R\u00e9adaptation et Clinique Romande de R\u00e9adaptation, SUVACare, Sion;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijan","family":"Najafi","sequence":"additional","affiliation":[{"name":"Laboratory of Movement Analysis and Measurement, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne;"},{"name":"Scholl's Center for Lower Extremity Ambulatory Research, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Ballabeni","sequence":"additional","affiliation":[{"name":"Institut de Recherche en R\u00e9adaptation et Clinique Romande de R\u00e9adaptation, SUVACare, Sion;"},{"name":"Institute of Social and Preventive Medicine, University of Lausanne, Lausanne;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoinette","family":"Crettenand","sequence":"additional","affiliation":[{"name":"Institut de Recherche en R\u00e9adaptation et Clinique Romande de R\u00e9adaptation, SUVACare, Sion;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Gobelet","sequence":"additional","affiliation":[{"name":"Institut de Recherche en R\u00e9adaptation et Clinique Romande de R\u00e9adaptation, SUVACare, Sion;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamiar","family":"Aminian","sequence":"additional","affiliation":[{"name":"Laboratory of Movement Analysis and Measurement, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Rizzoli","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, University Hospital of Geneva, World Health Organization Collaborating Center for Osteoporosis, Geneva; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Gremion","sequence":"additional","affiliation":[{"name":"University Hospital for Orthopaedic Surgery, Lausanne, Switzerland; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4018\/978-1-59140-836-9.ch003"},{"key":"B2","unstructured":"Armitage P , Berry G , Matthews JNS.Statistical Methods in Medical Research. 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