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Phosphorus-31 magnetic resonance and near-infrared spectroscopy were used simultaneously to monitor intramuscular acid-base status, high-energy phosphates, and muscle oxygenation. Resting intracellular hydrogen ion concentration ([H<jats:sup>+<\/jats:sup>]<jats:sub>i<\/jats:sub>) was lower ( P &lt; 0.05) in Hyp [90 nM (SD 3)] than Con [96 nM (SD 4)]; however, at end exercise, [H<jats:sup>+<\/jats:sup>]<jats:sub>i<\/jats:sub>was greater ( P &lt; 0.05) in Hyp [128 nM (SD 19)] than Con [120 nM (SD 17)]. At rest, [PCr] was not different between Con [36 mM (SD 2)] and Hyp [36 mM (SD 1)]. The time constant (\u03c4) of PCr breakdown during transition from rest to exercise was greater ( P &lt; 0.05) in Hyp [39 s (SD 22)] than Con [32 s (SD 22)], and the PCr amplitude was greater ( P &lt; 0.05) in Hyp [26% (SD 4)] than Con [22% (SD 6)]. The deoxyhemoglobin and\/or deoxymyoglobin (HHb) \u03c4 was similar between Hyp [13 s (SD 8)] and Con [10 s (SD 3)]; however, the amplitude was increased ( P &lt; 0.05) in Hyp [40 arbitrary units (au) (SD 23)] compared with Con [26 au (SD 17)]. In conclusion, our results indicate that Hyp-induced hypocapnia enhanced substrate-level phosphorylation during moderate-intensity exercise. In addition, the increased amplitude of the HHb response suggests a reduced local muscle perfusion in Hyp compared with Con.<\/jats:p>","DOI":"10.1152\/japplphysiol.00895.2006","type":"journal-article","created":{"date-parts":[[2007,1,12]],"date-time":"2007-01-12T01:34:46Z","timestamp":1168565686000},"page":"1565-1573","source":"Crossref","is-referenced-by-count":30,"title":["Effects of hyperventilation on phosphocreatine kinetics and muscle deoxygenation during moderate-intensity plantar flexion exercise"],"prefix":"10.1152","volume":"102","author":[{"given":"S. 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