{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:31:10Z","timestamp":1787725870205,"version":"build-2784847793"},"reference-count":64,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:p>Direct recordings from human motoneurons are not feasible; therefore, synaptic inhibition must be estimated indirectly. Experiments on rat brain slices allow accurate prediction of inhibition duration, independent of motor unit discharge rate. Applying these predictions in human studies has revealed discharge rate-independent functional inhibitions across various brainstem and spinal circuits. This approach offers robust estimates of functional inhibition, with potential clinical applications for monitoring neurological disorders that affect neural circuits.<\/jats:p>","DOI":"10.1152\/japplphysiol.00912.2025","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T15:32:57Z","timestamp":1769787177000},"page":"639-651","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A novel method to estimate discharge-independent inhibition durations of spinal and brainstem circuits in humans"],"prefix":"10.1152","volume":"140","author":[{"given":"Betilay","family":"Topkara Arslan","sequence":"first","affiliation":[{"name":"Bah\u00e7e\u015fehir University","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-1174","authenticated-orcid":false,"given":"M. G\u00f6rkem","family":"\u00d6zyurt","sequence":"additional","affiliation":[{"name":"University College London","place":["United Kingdom"]},{"name":"Queen Square Institute of Neurology, University College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal Sitki","family":"T\u00fcrker","sequence":"additional","affiliation":[{"name":"Istanbul Geli\u015fim University","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adz5524"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1113\/JP277129"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.09.021"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad342"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn050"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1974.tb05707.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235884"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00249617"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp015944"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(88)90130-x"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.2.829"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.044982"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.05.007"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.05.010"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.73.5.1799"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.401be.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(78)90017-2"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-0270(02)00321-7"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(85)90083-4"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00064.2017"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90070-6"},{"key":"B22","first-page":"31","volume":"17","author":"Corsi FM","year":"2002","journal-title":"Funct Neurol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.01.002"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880160306"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.07.031"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26308"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-9969(96)00112-4"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(89)90050-2"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1589-20.2020"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/BF00232447"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90137-x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i1.177"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.18103\/mra.v13i5.6561"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2380-6"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2002.1o085.x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.12.055"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2019.73.326-330"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2023.11.013"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.10.033"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90955-5"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(87)90007-4"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.44.11.2148"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/s1388-2457(02)00334-6"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/BF02333781"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/BF00231458"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.6.991"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.115046"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13758"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1981.46.6.1349"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229628"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016681"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.2.417"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90542-j"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00719"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/579242"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg3904"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00021.2018"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.08.009"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1113\/JP282565"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1113\/JP278675"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23224-7"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00184.2022"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.71385"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1113\/JP285348"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00912.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:21:26Z","timestamp":1774304486000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00912.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,1]]}},"alternative-id":["10.1152\/japplphysiol.00912.2025"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00912.2025","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]},"assertion":[{"value":"2025-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}