{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:12:02Z","timestamp":1791313922931,"version":"4.3.1"},"reference-count":58,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs (Chaires de recherche du Canada)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de recherche en sant\u00e9 du Canada)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:p>The involvement of gastroesophageal refluxes in cardiorespiratory events of preterm infants remains controversial. While a few studies in full-term newborn animals have shown that stimulation of esophageal receptors leads to cardiorespiratory reflexes, the latter remain largely unknown, especially after premature birth. The present study aimed to 1) characterize the cardiorespiratory reflexes originating from esophageal receptors in newborn lambs and 2) test the hypotheses that preterm birth enhances reflex cardiorespiratory inhibition and that C-fibers are involved in these reflexes. Eight full-term lambs and 10 lambs born 14 days prematurely were studied. Following surgical instrumentation, a 6-h polysomnography was performed without sedation to record electrocardiogram, respiratory movements, arterial pressure, laryngeal constrictor muscle activity, state of alertness, and hemoglobin oxygen saturation. Five esophageal stimulations of the upper and\/or lower esophagus, including rapid balloon inflation and\/or HCl injection, were performed in random order. A second recording was performed in full-term lambs 24 h later, after C-fiber blockade by capsaicin. Results confirmed that esophageal stimulations induced inhibitory cardiorespiratory reflexes combined with protective mechanisms, including laryngeal closure, swallowing, coughing, increased arterial pressure, and arousal. Preterm birth heightened cardiorespiratory inhibition. The strongest cardiorespiratory inhibition was observed following simultaneous stimulation of the lower and upper esophagus. Finally, cardiorespiratory inhibition was decreased after C-fiber blockade. In conclusion, esophageal stimulation induces inhibitory cardiorespiratory reflexes, which are partly mediated by C-fibers and more pronounced in preterm lambs. Clinical relevance of these findings requires further studies, especially in conditions associated with increased cardiorespiratory events, e.g., neonatal infection.<\/jats:p>\n                  <jats:p>NEW &amp; NOTEWORTHY Preterm birth heightens the cardiorespiratory events triggered by esophageal stimulation. The most extensive cardiorespiratory events are induced by simultaneous stimulation of the proximal and distal esophagus.<\/jats:p>","DOI":"10.1152\/japplphysiol.00915.2016","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T20:10:31Z","timestamp":1496347831000},"page":"489-497","source":"Crossref","is-referenced-by-count":8,"title":["Reflex cardiorespiratory events from esophageal origin are heightened by preterm birth"],"prefix":"10.1152","volume":"123","author":[{"given":"St\u00e9phanie","family":"Nault","sequence":"first","affiliation":[{"name":"Neonatal Respiratory Research Unit, Departments of Pediatrics and Pharmacology-Physiology, Universit\u00e9 de Sherbrooke, Quebec, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Samson","sequence":"additional","affiliation":[{"name":"Neonatal Respiratory Research Unit, Departments of Pediatrics and Pharmacology-Physiology, Universit\u00e9 de Sherbrooke, 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