{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:52:44Z","timestamp":1774453964767,"version":"3.50.1"},"reference-count":54,"publisher":"American Physiological Society","issue":"8","funder":[{"DOI":"10.13039\/501100000844","name":"European Space Agency (ESA)","doi-asserted-by":"publisher","award":["4000111808\/14\/NL\/NDe"],"award-info":[{"award-number":["4000111808\/14\/NL\/NDe"]}],"id":[{"id":"10.13039\/501100000844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001859","name":"Swedish National Space Board (Svenska Rymdstyrelsen)","doi-asserted-by":"publisher","award":["109\/11:2"],"award-info":[{"award-number":["109\/11:2"]}],"id":[{"id":"10.13039\/501100001859","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2016,4,15]]},"abstract":"<jats:p> Independently, both inactivity and hypoxia augment oxidative stress. This study, part of the FemHab project, investigated the combined effects of bed rest-induced unloading and hypoxic exposure on oxidative stress and antioxidant status. Healthy, eumenorrheic women were randomly assigned to the following three 10-day experimental interventions: normoxic bed rest (NBR; n = 11; Pi<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub> = 133 mmHg), normobaric hypoxic bed rest (HBR; n = 12; Pi<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub> = 90 mmHg), and ambulatory hypoxic confinement (HAMB; n = 8: Pi<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub> = 90 mmHg). Plasma samples, obtained before (Pre), during (D2, D6), immediately after (Post) and 24 h after (Post+1) each intervention, were analyzed for oxidative stress markers [advanced oxidation protein products (AOPP), malondialdehyde (MDA), and nitrotyrosine], antioxidant status [superoxide dismutase (SOD), catalase, ferric-reducing antioxidant power (FRAP), glutathione peroxidase (GPX), and uric acid (UA)], NO metabolism end-products (NOx), and nitrites. Compared with baseline, AOPP increased in NBR and HBR on D2 (+14%; +12%; P &lt; 0.05), D6 (+19%; +15%; P &lt; 0.05), and Post (+22%; +21%; P &lt; 0.05), respectively. MDA increased at Post+1 in NBR (+116%; P &lt; 0.01) and D2 in HBR (+114%; P &lt; 0.01) and HAMB (+95%; P &lt; 0.05). Nitrotyrosine decreased (\u221245%; P &lt; 0.05) and nitrites increased (+46%; P &lt; 0.05) at Post+1 in HAMB only. Whereas SOD was higher at D6 (+82%) and Post+1 (+67%) in HAMB only, the catalase activity increased on D6 (128%) and Post (146%) in HBR and HAMB, respectively ( P &lt; 0.05). GPX was only reduced on D6 (\u221220%; P &lt; 0.01) and Post (\u221218%; P &lt; 0.05) in HBR. No differences were observed in FRAP and NOx. UA was higher at Post in HBR compared with HAMB ( P &lt; 0.05). These data indicate that exposure to combined inactivity and hypoxia impairs prooxidant\/antioxidant balance in healthy women. Moreover, habitual activity levels, as opposed to inactivity, seem to blunt hypoxia-related oxidative stress via antioxidant system upregulation. <\/jats:p>","DOI":"10.1152\/japplphysiol.00919.2015","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T21:55:14Z","timestamp":1453413314000},"page":"930-938","source":"Crossref","is-referenced-by-count":21,"title":["FemHab: The effects of bed rest and hypoxia on oxidative stress in healthy women"],"prefix":"10.1152","volume":"120","author":[{"given":"Tadej","family":"Debevec","sequence":"first","affiliation":[{"name":"Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Pialoux","sequence":"additional","affiliation":[{"name":"Center of Research and Innovation on Sports, University Claude Bernard Lyon 1, Villeurbanne, 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