{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T15:17:28Z","timestamp":1794410248750,"version":"4.9.0"},"reference-count":51,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100013981","name":"American Academy of Sleep Medicine Foundation","doi-asserted-by":"publisher","award":["277-JF-22"],"award-info":[{"award-number":["277-JF-22"]}],"id":[{"id":"10.13039\/100013981","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["CDA#940501"],"award-info":[{"award-number":["CDA#940501"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012893","name":"HHS | NIH | Division of Loan Repayment","doi-asserted-by":"publisher","award":["LRP"],"award-info":[{"award-number":["LRP"]}],"id":[{"id":"10.13039\/100012893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1HL148436"],"award-info":[{"award-number":["RO1HL148436"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL161336"],"award-info":[{"award-number":["K23HL161336"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000100"],"award-info":[{"award-number":["UL1TR000100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001442"],"award-info":[{"award-number":["UL1TR001442"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CDA-2 IK2CX002524-01A2"],"award-info":[{"award-number":["CDA-2 IK2CX002524-01A2"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:p> Our data provide important insights into obesity-related obstructive sleep apnea (OSA) pathogenesis, thereby validating, and extending, prior research findings. This is the largest sample size study to examine the relationships between obesity and gender on OSA pathogenesis. The influence of obesity on sleep apnea severity is mediated by different mechanistic traits (endotypes). <\/jats:p>","DOI":"10.1152\/japplphysiol.00925.2023","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T08:01:42Z","timestamp":1714032102000},"page":"1516-1525","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Effect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort"],"prefix":"10.1152","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-7545","authenticated-orcid":false,"given":"Brandon","family":"Nokes","sequence":"first","affiliation":[{"name":"Sleep Medicine Section, Veterans Affairs San Diego Healthcare System, San Diego, California, United States"},{"name":"Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-5337","authenticated-orcid":false,"given":"Jeremy E.","family":"Orr","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"White","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Luu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raichel","family":"Alex","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Sands","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Wojeck","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Yale School of Medicine, New Haven, Connecticut, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6515-6204","authenticated-orcid":false,"given":"Robert L.","family":"Owens","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher N.","family":"Schmickl","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30198-5"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws342"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/2012.jama.11580"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201903-0692OC"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.23.3015"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz274"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00045.2008"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00410.2004"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201404-0783OC"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201707-1435OC"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx183"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00062914"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.3.1055"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00212711"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200209-1055OC"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00080.2010"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.2003131"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.4.323"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.2.362"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2112072"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3433"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.064238"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2558"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00264.2002"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy624"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac050"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00561.2007"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5516"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2390"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-80519-7"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.3.9911064"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0278"},{"key":"B34","first-page":"499","volume":"110","author":"Ashraf MJ","year":"2013","journal-title":"Mo Med"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3202"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.4.449"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2509"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202005-1808OC"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.171016"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.05.033"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201804-0758OC"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1042\/CS20100588"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s40675-018-0121-8"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201404-0718OC"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-005-0002-5"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3844"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac158"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac310"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.2009032"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1207\/s15327906mbr3001_3"},{"key":"B51","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: a Regression-Based Approach","author":"Hayes A","year":"2022"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00925.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T19:43:08Z","timestamp":1718394188000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00925.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,1]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,1]]}},"alternative-id":["10.1152\/japplphysiol.00925.2023"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00925.2023","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,1]]},"assertion":[{"value":"2024-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}