{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:41:36Z","timestamp":1790872896737,"version":"4.1.0"},"reference-count":29,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>To model lung nitric oxide (NO) and carbon monoxide (CO) uptake, a membrane oxygenator circuit was primed with horse blood flowing at 2.5 l\/min. Its gas channel was ventilated with 5 parts\/million NO, 0.02% CO, and 22% O<jats:sub>2<\/jats:sub>at 5 l\/min. NO diffusing capacity (Dno) and CO diffusing capacity (Dco) were calculated from inlet and outlet gas concentrations and flow rates: Dno = 13.45 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7Torr<jats:sup>\u22121<\/jats:sup>(SD 5.84) and Dco = 1.22 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7Torr<jats:sup>\u22121<\/jats:sup>(SD 0.3). Dno and Dco increased ( P = 0.002) with blood volume\/surface area. 1\/Dno ( P &lt; 0.001) and 1\/Dco ( P &lt; 0.001) increased with 1\/Hb. Dno ( P = 0.01) and Dco ( P = 0.004) fell with increasing gas flow. Dno but not Dco increased with hemolysis ( P = 0.001), indicating Dno dependence on red cell diffusive resistance. The posthemolysis value for membrane diffusing capacity = 41 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7Torr<jats:sup>\u22121<\/jats:sup>is the true membrane diffusing capacity of the system. No change in Dno or Dco occurred with changing blood flow rate. 1\/Dco increased ( P = 0.009) with increasing Po<jats:sub>2<\/jats:sub>. Dno and Dco appear to be diffusion limited, and Dco reaction limited. In this apparatus, the red cell and plasma offer a significant barrier to NO but not CO diffusion. Applying the Roughton-Forster model yields similar specific transfer conductance of blood per milliliter for NO and CO to previous estimates. This approach allows alteration of membrane area\/blood volume, blood flow, gas flow, oxygen tension, red cell integrity, and hematocrit (over a larger range than encountered clinically), while keeping other variables constant. Although structurally very different, it offers a functional model of lung NO and CO transfer.<\/jats:p>","DOI":"10.1152\/japplphysiol.00949.2005","type":"journal-article","created":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T01:40:11Z","timestamp":1136511611000},"page":"1527-1538","source":"Crossref","is-referenced-by-count":28,"title":["Can a membrane oxygenator be a model for lung NO and CO transfer?"],"prefix":"10.1152","volume":"100","author":[{"given":"Colin","family":"Borland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Dunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Bottrill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Vuylsteke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","unstructured":"Bidani A, Tao W, and Zwischenberger JB.Testing and performance evaluation of artificial lungs. In:The Artificial Lung, edited by Vaslef SN and Anderson RW Georgetown, TX: Landes Bioscience, 2002."},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-199911000-00008"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.2.538"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Borland CDRand Higenbottam TW.A simultaneous single breath measurement of pulmonary diffusing capacity with nitric oxide and carbon monoxide.Eur Respir J2: 56\u201363, 1989.","DOI":"10.1183\/09031936.93.02010056"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Borland C.NO and CO transfer.Eur Respir J3: 977\u2013978, 1990.","DOI":"10.1183\/09031936.93.03080977"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1042\/cs0810759"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.42.1.83"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00469.2004"},{"key":"R9","unstructured":"Cotes JE.Lung Function: Assessment and Application in Medicine.Oxford, UK: Blackwell Scientific, 1993, p. 297\u2013301."},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1042\/cs0420325"},{"key":"R11","unstructured":"Coulson JMand Richardson JF.Mass transfer. In:Coulson and Richardson's Chemical Engineering. Fluid Flow, Heat Transfer, and Mass Transfer(6th ed.). Amsterdam: Elsevier, 1999, vol I. chapt. 10."},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(00)80291-3"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Forster RE.Diffusion of gases across the alveolar membrane. In:Handbook of Physiology. The Respiratory System. Gas Exchange.Bethesda, MD: Am. Physiol. Soc. 1987, sect. 3, vol. IV, chapt. 5, p. 71\u201388.","DOI":"10.1002\/cphy.cp030405"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1177\/026765919400900304"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(89)90027-3"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(87)80036-1"},{"key":"R17","unstructured":"Hattler BGand Federspiel WJ.Gas exchange in the venous system. In:The Artificial Lung, edited by Vaslef SN and Anderson RW. Georgetown, TX: Landes Bioscience, 2002."},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.6.2066"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(69)90068-1"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.5.1774"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2003.08.004"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.68.6.2344"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Moinard Jand Guenard H.Membrane diffusion of the lungs in patients with chronic renal failure.Eur Respir J6: 225\u2013230, 1999.","DOI":"10.1183\/09031936.93.06020225"},{"key":"R24","unstructured":"Piiper Jand Scheid P.Blood-gas equilibration in lungs. In:Pulmonary Gas Exchange Ventilation, Blood Flow And Diffusion, edited by West JB. New York: Academic, 1980."},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(92)90025-R"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1957.11.2.269"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1957.11.2.290"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1177\/026765919701200604"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(97)90096-3"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00949.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T03:15:51Z","timestamp":1683342951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00949.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1152\/japplphysiol.00949.2005"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00949.2005","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}