{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:42:54Z","timestamp":1789054974093,"version":"build-2803163510"},"reference-count":71,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000026","name":"HHS | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA053551"],"award-info":[{"award-number":["R21DA053551"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:p>Nalfurafine, a \u03ba-opioid receptor (\u03baOR) agonist, can reverse fentanyl-induced muscle rigidity and respiratory depression without affecting sedation. In nonanesthetized rats, nalfurafine (1 mg\/kg) effectively reversed muscle rigidity and restored ventilation to prefentanyl levels even though the animals remained fully sedated. U50488, another \u03baOR agonist, did not reproduce the results. These findings suggest that nalfurafine is a promising therapeutic to mitigate fentanyl\u2019s side effects while maintaining the benefits.<\/jats:p>","DOI":"10.1152\/japplphysiol.00952.2024","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T12:31:21Z","timestamp":1744374681000},"page":"1161-1172","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Nalfurafine reverses fentanyl-induced muscle rigidity and respiratory depression without affecting sedation in rats: decoupling respiration from sedation"],"prefix":"10.1152","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-5045","authenticated-orcid":false,"given":"Tristan","family":"Lewis","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xjacd83","id-type":"ROR","asserted-by":"publisher"}],"name":"Cleveland Clinic","place":["United States"]},{"name":"Case Western Reserve University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-4254","authenticated-orcid":false,"given":"Philippe","family":"Haouzi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xjacd83","id-type":"ROR","asserted-by":"publisher"}],"name":"Cleveland Clinic","place":["United States"]},{"id":[{"id":"https:\/\/ror.org\/03xjacd83","id-type":"ROR","asserted-by":"publisher"}],"name":"Cleveland Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen094"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2017.10.010"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.56973"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.258566"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108974"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2020.173077"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06125-5"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00819.2021"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003156"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199609000-00034"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198704000-00030"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90252-8"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90728-r"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90723-x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)12162-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198908000-00013"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199609000-00017"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0390-08.2008"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1021\/jm301783x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1994.1015"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.12.4308"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.255661"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4652-3"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S55942"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113939"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2020.103428"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000005324"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91011-5"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13561.x"},{"key":"B33","volume-title":"StatPearls","author":"Harb A","year":"2025"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00126.2009"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.aat.2015.03.003"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198404000-00027"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1988.01400250076013"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2016.1157722"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198906000-00017"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1989.tb02849.x"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000001185"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-0173(03)00143-7"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/s0079-6123(08)63799-1"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.9.3419"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jflm.2024.102780"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-8730-4_4"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/164_2020_430"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp588"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1159\/000341268"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.5414\/CP201852"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2009.45.5.1362067"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4758-7"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.09.036"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.120.000387"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200109000-00029"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00185.2012"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000628"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50613-2"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153200"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001303"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200712-1901OC"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00755.2007"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000270760.46821.67"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2016.10.004"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010263431705"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197505222922106"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200105000-00021"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.4236\/ojmip.2013.34022"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.4236\/ojmip.2013.33019"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.04.024"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005853"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1441-0"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-020-00519-1"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114785"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00952.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T10:42:40Z","timestamp":1747737760000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.00952.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":71,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,1]]}},"alternative-id":["10.1152\/japplphysiol.00952.2024"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00952.2024","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,1]]},"assertion":[{"value":"2024-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}