{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:08:09Z","timestamp":1791655689114,"version":"4.3.4"},"reference-count":48,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en G\u00e9nie du Canada)","doi-asserted-by":"publisher","award":["250367-11"],"award-info":[{"award-number":["250367-11"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:p>Recently, dietary nitrate supplementation has been shown to improve exercise capacity in healthy individuals through a potential nitrate-nitrite-nitric oxide pathway. Nitric oxide has been shown to play an important role in compensatory vasodilation during exercise under hypoperfusion. Previously, we established that certain individuals lack a vasodilation response when perfusion pressure reductions compromise exercising muscle blood flow. Whether this lack of compensatory vasodilation in healthy, young individuals can be restored with dietary nitrate supplementation is unknown. Six healthy (21\u2009\u00b1\u20092 yr), recreationally active men completed a rhythmic forearm exercise. During steady-state exercise, the exercising arm was rapidly transitioned from an uncompromised (below heart) to a compromised (above heart) position, resulting in a reduction in local pressure of \u221231\u2009\u00b1\u20091 mmHg. Exercise was completed following 5 days of nitrate-rich (70 ml, 0.4 g nitrate) and nitrate-depleted (70 ml, ~0 g nitrate) beetroot juice consumption. Forearm blood flow (in milliliters per minute; brachial artery Doppler and echo ultrasound), mean arterial blood pressure (in millimeters of mercury; finger photoplethysmography), exercising forearm venous effluent (ante-cubital vein catheter), and plasma nitrite concentrations (chemiluminescence) revealed two distinct vasodilatory responses: nitrate supplementation increased (plasma nitrite) compared with placebo (245\u2009\u00b1\u200960 vs. 39\u2009\u00b1\u20099 nmol\/l; P &lt; 0.001), and compensatory vasodilation was present following nitrate supplementation (568 \u00b1 117 vs. 714 \u00b1 139 ml \u22c5 min<jats:sup>\u22121<\/jats:sup>\u22c5 100 mmHg<jats:sup>\u22121<\/jats:sup>; P = 0.005) but not in placebo (687 \u00b1 166 vs. 697 \u00b1 171 min<jats:sup>\u22121<\/jats:sup>\u22c5 100 mmHg<jats:sup>\u22121<\/jats:sup>; P = 0.42). As such, peak exercise capacity was reduced to a lesser degree (\u22124 \u00b1 39 vs. \u221239 \u00b1 27 N; P = 0.01). In conclusion, dietary nitrate supplementation during a perfusion pressure challenge is an effective means of restoring exercise capacity and enabling compensatory vasodilation.<\/jats:p><jats:p>NEW &amp; NOTEWORTHY Previously, we identified young, healthy persons who suffer compromised exercise tolerance when exercising muscle perfusion pressure is reduced as a result of a lack of compensatory vasodilation. The ability of nitrate supplementation to restore compensatory vasodilation in such noncompensators is unknown. We demonstrated that beetroot juice supplementation led to compensatory vasodilation and restored perfusion and exercise capacity. Elevated plasma nitrite is an effective intervention for correcting the absence of compensatory vasodilation in the noncompensator phenotype.<\/jats:p>","DOI":"10.1152\/japplphysiol.00953.2016","type":"journal-article","created":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T01:10:28Z","timestamp":1496970628000},"page":"594-605","source":"Crossref","is-referenced-by-count":23,"title":["Dietary nitrate restores compensatory vasodilation and exercise capacity in response to a compromise in oxygen delivery in the noncompensator phenotype"],"prefix":"10.1152","volume":"123","author":[{"given":"Robert F.","family":"Bentley","sequence":"first","affiliation":[{"name":"School of Kinesiology and Health Studies, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J.","family":"Walsh","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Health Studies, Queen\u2019s University, Kingston, Ontario, 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